国际医药卫生导报2025，Vol.31Issue(12)：2093-2097,5.DOI:10.3760/cma.j.cn441417-20241029-12032
多学科协作对乳腺癌化疗致周围神经病变患者的作用
Effect of multidisciplinary collaboration for Chemotherapy induced peripheral neuropathy in Patients with breast cancer
摘要
Abstract
Objective To explore the actual effectiveness and feasibility of multidisciplinary collaborative nursing interventions in alleviating symptoms of chemotherapy-induced peripheral neuropathy(CIPN)after breast cancer chemotherapy.Methods A single-center prospective randomized controlled trial was conducted.The study involved 128 patients with CIPN treated at Shaanxi Provincial Cancer Hospital from February 2022 to January 2024.The patients were randomly divided into a control group and a study group,each consisting of 64 patients.The control group including 1 male and 63 females,aged 31-56(32.84±2.75)years;the study group including 1 male and 63 females,aged 36-52(33.27±3.17)years.The control group received routine nursing care,while the study group was administered a multidisciplinary nursing intervention protocol in addition to standard care.Both groups received the allocated interventions for 3 months.Medical Coping Modes Questionnaire(MCMQ),Herth Hope Index(HHI),Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),Visual Analogue Scale(VAS)for pain,and the Neurotoxicity Quality of Life Scale(FACT/GOG Ntx)score of the American Cancer Treatment Functional Evaluation System were compared between two groups.t test and x2 test were used for statistically analysis.Results After three months of intervention,the study group showed lower scores in the dimensions of submission and avoidance compared to the control group[(12.57±2.64)points vs.(14.13±3.18)points and(14.62±2.23)points vs.(17.28±2.56)points],while the score of the facing dimension was higher than the control group[(19.13±2.82)points vs.(17.65±2.63)points](all P＜0.05).The study group demonstrated significantly higher HHI scores compared to the control group[(40.81±4.51)points vs.(36.67±4.26)points],but showing lower scores on both SAS and SDS[(55.82±5.24)vs.(60.19±5.73)points and(54.18±6.04)points vs.(59.57±6.38)points],with all differences being statistically significant(all P＜0.05).The study group demonstrated significantly lower neuropathic pain VAS scores than the control group at both 1-month and 3-month post-chemotherapy[(1.83±0.73)points vs.(2.46±0.86)points、(0.58±0.17)points vs.(1.04±0.39)points].Similarly,FACT/GOG-Ntx scores were significantly reduced in the study group compared to the control group at both 1-month and 3-month post-chemotherapy[(7.23±1.86)points vs.(10.84±2.49)points and(3.56±1.12)points vs.(5.27±1.58)points](t=9.292 and 7.064,both P＜0.05).Conclusion Nursing interventions within a multidisciplinary context effectively improve the psychological state,pain level,and quality of life of patients suffering from CIPN following breast cancer chemotherapy.关键词
乳腺癌/多学科护理干预/化疗/周围神经病变/生活质量Key words
Breast cancer/Multidisciplinary nursing intervention/Chemotherapy/Peripheral neuropathy/Quality of life引用本文复制引用
王效,邓智平,张习凡,李阳,张彧..多学科协作对乳腺癌化疗致周围神经病变患者的作用[J].国际医药卫生导报,2025,31(12):2093-2097,5.基金项目
陕西省重点研发计划(2022SF-488) Key Research and Development Program of Shaanxi Province(2022SF-488) （2022SF-488）
