广东药科大学学报2025，Vol.41Issue(3)：163-171,9.DOI:10.16809/j.cnki.2096-3653.2024122505
空气颗粒物对巨噬细胞氧化应激、免疫应答及癌症诱发机制的研究进展
Research progress on the oxidative stress,immune response,and cancer induction mechanism of macrophages by airborne particulate matter
摘要
Abstract
Particulate matter(PM)is a major component of environmental pollution.There are increasing concerns about its impact on human health,especially regarding its effects on macrophage-mediated oxidative stress and immune responses in promoting tumorigenesis.Macrophages play a key role in the body's immune system and serve as the first line of defense against airborne particulate matter invasion.Recent studies have demonstrated that PM strongly affects macrophage function by inducing oxidative stress responses,thereby playing a crucial role in immune reaction.These changes not only compromise the body's defense against pathogens,but may also promote the establishment and progression of cancer through inflammation-related mechanisms.While studies have proposed how PM interferes with macrophage function,the biological effects vary significantly,and their underlying mechanisms remain unresolved.Therefore,this article aims to systematically review the effects of air particulate matter on macrophages,explore its role in oxidative stress,immune response,and tumor development,analyze existing research results,and propose future research directions,providing reference for research in related fields.关键词
空气颗粒物/巨噬细胞/氧化应激/免疫应答/肿瘤发生Key words
particulate matter/macrophages/oxidative stress/immune response/tumorigenesis分类
医药卫生引用本文复制引用
冯子倍,郭晓兰,朱慧娟,叶治莲,林玉茵,李江超..空气颗粒物对巨噬细胞氧化应激、免疫应答及癌症诱发机制的研究进展[J].广东药科大学学报,2025,41(3):163-171,9.基金项目
国家自然科学基金青年项目(82300056) （82300056）
