黑龙江八一农垦大学学报2025，Vol.37Issue(3)：37-43,7.DOI:10.3969/j.issn.1002-2090.2025.03.006
氟西汀改善慢性不可预见温和应激诱导的猪抑郁样状态
Protective Effect of Fluoxetine on Depressive-like State in Pigs after Chronic Unforeseeable Mild Stress
摘要
Abstract
In the intensive production of pigs,the chronic stress caused by the barren environment,narrow space and other factors has a serious negative impact on the behavior and physiology of pigs,causing them to produce a depression-like state,and then affecting the welfare of pigs.In order to explore a feasible method to improve depressive-like state of pigs,16 adult Bamea pigs modeled by Chronic Unforeseeable Mild Stress(CUMS)were randomly divided into fluoxetine treatment group(n=8)and natural recovery treatment group(n=8).The fluoxetine treatment group was given fluoxetine for 4 weeks and without any intervention in the natural recovery treatment group.The results showed that fluoxetine increased the sugar water preference rate of pigs at 2 and 4 weeks after modeling,reduced the incubation period of exposure to novelty stimulus,and increased the number and time of exposure to novelty stimulus at 4 weeks after modeling.At the same time,fluoxetine could also reduce the serum corticotropin releasing hormone(COR)content of pigs at 4 weeks after modeling,but had no effect on the serum adrenocorticotrophic hormone(ACTH)content.It reduced the relative expression level of miR-34a,increased the relative expression levels of miR-16 and miR-124 in the hippocampus of pigs at 4 weeks after modeling.In conclusion,fluoxetine intervention could effectively improve the depression-like behavior of CUMS pigs,reduce the content of COR in blood,regulate the expression of miRNA in the hippocampus,and improve the welfare level of pigs in the intensive feeding process.关键词
CUMS/氟西汀/抑郁样状态/猪Key words
CUMS/fluoxetine/depression-like state/pig分类
农业科技引用本文复制引用
赵帅,郑强,杨森,崔卫国,尹国安..氟西汀改善慢性不可预见温和应激诱导的猪抑郁样状态[J].黑龙江八一农垦大学学报,2025,37(3):37-43,7.基金项目
2022年度引进定向培养人才科研启动基金项目(XYB202209). （XYB202209）
