国际医药卫生导报2025，Vol.31Issue(11)：1770-1774,5.DOI:10.3760/cma.j.cn441417-20250123-11002
黄芪宗气方治疗冠心病合并心力衰竭患者的效果及对血管内皮功能影响
The efficacy of Huangqi Zongqi Formula in treating patients with coronary heart disease complicated with heart failure and its impact on vascular endothelial function
摘要
Abstract
Objective To explore the efficacy of the Huangqi Zongqi Formula in treating patients with coronary heart disease combined with heart failure and its impact on vascular endothelial function.Methods A total of 98 patients with coronary heart disease and heart failure who were admitted to the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from October 2021 to October 2024 were selected as the research subjects.The patients were divided into the traditional Chinese medicine group and the conventional group using the random number table method,with 49 cases in each group.There were 27 males and 22 females in the traditional Chinese medicine group,aged 45-81(62.10±8.05)years,course of coronary heart disease 4-13(8.43±2.09)years,course of heart failure 1-5(2.61±0.70)years,New York Heart Association(NYHA)classification:13 cases at grade Ⅱ,25 cases at grade Ⅲ,and 11 cases at grade Ⅳ.There were 25 males and 24 females in the conventional group,aged 44-82(63.20±8.78)years,course of coronary heart disease 3-12(8.08±1.96)years,course of heart failure 1-5(2.67±0.66)years,NYHA classification:15 cases at grade Ⅱ,24 cases at grade Ⅲ,and 10 cases at grade Ⅳ.The conventional group received conventional Western medical treatment,while the traditional Chinese medicine group was treated with the Huangqi Zongqi Formula in addition to the treatment provided by the conventional group.Both groups were treated continuously for 8 weeks.Compare the clinical efficacy of the two groups;vascular endothelial function(endothelin-1,nitric oxide),cardiac function[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),B-type natriuretic peptide(BNP)],heart failure symptoms(Lee's heart failure score),and quality of life[Minnesota heart failure quality of life questionnaire(MLHFQ)]before and after treatment.Independent sample t test,paired t test,and x2 test were used for statistical analysis.Results The total effective rate of the traditional Chinese medicine group was higher than that of the conventional group[91.84％(45/49)vs.73.47％(36/49)](P＜0.05).After treatment,the level of endothelin-1 in the traditional Chinese medicine group was lower than that in the conventional group[(43.98±3.30)ng/L vs.(51.31±3.88)ng/L],and the level of nitric oxide was higher than that in the conventional group[(39.33±2.99)μmol/L vs.(35.15±1.37)μmol/L](both P＜0.05);the LVEF of the traditional Chinese medicine group was higher than that of the conventional group[(58.14±3.57)％vs.(55.06±4.43)％],while the LVESD,LVEDD and BNP levels were all lower in the traditional Chinese medicine group[(46.41±3.96)mm vs.(49.57±2.32)mm,(46.61±3.03)mm vs.(52.92±3.25)mm,(454.36±90.21)ng/L vs.(506.58±76.30)ng/L](all P＜0.05);the Lee's heart failure score and the MLHFQ score in the traditional Chinese medicine group were both lower than those in the conventional group[(7.47±1.60)points vs.(9.29±1.44)points,(38.12±4.60)points vs.(45.27±4.71)points](both P＜0.05).Conclusion The Huangqi Zongqi Formula combined with other treatments for coronary heart disease complicated with heart failure has a better therapeutic effect.It can improve vascular endothelial function,cardiac function and symptoms of heart failure,and enhance the quality of life.关键词
冠心病/心力衰竭/黄芪宗气方/血管内皮功能/生活质量Key words
Coronary heart disease/Heart failure/Huangqi Zongqi Formula/Vascular endothelial function/Quality of life引用本文复制引用
刘谊,韩宝华,张悦..黄芪宗气方治疗冠心病合并心力衰竭患者的效果及对血管内皮功能影响[J].国际医药卫生导报,2025,31(11):1770-1774,5.基金项目
国家自然科学基金(81774304) National Natural Science Foundation of China(81774304) （81774304）
