国际医药卫生导报2025，Vol.31Issue(11)：1775-1779,5.DOI:10.3760/cma.j.cn441417-20250123-11003
尿酸/高密度脂蛋白胆固醇比值预测老年慢性心力衰竭患者主要心血管不良事件的价值
The value of the uric acid/high-density lipoprotein cholesterol ratio in predicting major cardiovascular adverse events in elderly patients with chronic heart failure
摘要
Abstract
Objective To explore the value of the uric acid/high-density lipoprotein cholesterol ratio(UHR)in predicting major adverse cardiovascular events(MACE)in elderly patients with chronic heart failure(CHF).Methods A total of 96 elderly patients with CHF who were admitted to Yantai Laiyang Central Hospital from January 2021 to December 2023 were selected as the study subjects.There were 57 males and 39 females,with ages ranging from 60 to 80(70.46±8.25)years old.All patients were followed up for one year after discharge.Based on the occurrence of MACE,the patients were divided into the MACE group(27 cases)and the non-MACE group(69 cases).Collect the clinical data of the patients at the time of admission,including age,body mass index,gender,coexisting diseases(hypertension,coronary heart disease,cardiomyopathy,valvular disease),total cholesterol(TC),triglycerides(TG),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),smoking history,drinking history,uric acid(UA),high-density lipoprotein cholesterol(HDL-C),and UHR.Using binary logistic regression analysis,the influencing factors for the occurrence of MACE in elderly patients with CHF were investigated.The predictive efficacy of the receiver operating characteristic curve(ROC)was used to analyze the occurrence of MACE in elderly patients with CHF.Independent sample t test,and x2 test were used for statistical analysis.Results A total of 96 elderly patients with CHF were included in this study.They were followed up for one year after discharge,and a total of 27 cases developed MACE.The LVEDD and LVESD in the MACE group were longer than those in the non-MACE group[(65.21±8.34)mm vs.(48.57±8.63)mm,(64.97±5.74)mm vs.(48.02±5.28)mm],and the LVEF was lower in the MACE group[(40.83±5.12)％vs.(46.29±6.45)％](all P＜0.05).The levels of UA and UHR in the MACE group were higher than those in the non-MACE group[(467.12±84.08)μmol/L vs.(409.86±73.75)μmol/L,657.92±118.43 vs.333.22±66.65],while the level of HDL-C was lower in the MACE group[(0.71±0.13)mmol/L vs.(1.23±0.21)mmol/L](all P＜0.05).The results of the binary logistic regression analysis showed that high UA levels(OR=2.109,95％CI 1.109-4.010),low HDL-C levels(OR=0.438,95％CI 0.254-0.756),and high UHR(OR=10.549,95％CI 3.123-35.629)were all independent risk factors for the occurrence of MACE(all P＜0.05).The ROC results showed that the area under the curve(95％CI)of UHR in predicting the occurrence of MACE in elderly patients with CHF was 0.904(0.859-0.954),the cut-off value was 469.68,the specificity was 86.71％,and the sensitivity was 85.48％.Conclusion UHR is closely related to MACE in elderly patients with CHF and is expected to become a biomarker for predicting the occurrence of MACE in elderly patients with CHF.关键词
慢性心力衰竭/主要心血管不良事件/老年人/尿酸/高密度脂蛋白胆固醇比值/预测Key words
Chronic heart failure/Major cardiovascular adverse events/Elderly/Uric acid/high-density lipoprotein cholesterol ratio/Forecast引用本文复制引用
胡人月,曹晓媚,夏雪艳..尿酸/高密度脂蛋白胆固醇比值预测老年慢性心力衰竭患者主要心血管不良事件的价值[J].国际医药卫生导报,2025,31(11):1775-1779,5.基金项目
山东省医药卫生科技项目(202312071511) Shandong Province Medical and Health Science and Technology Project(202312071511) （202312071511）
