国际医药卫生导报2025，Vol.31Issue(11)：1780-1784,5.DOI:10.3760/cma.j.cn441417-20241230-11004
急性冠脉综合征患者炎症指数、血脂指标变化与冠状动脉病变严重程度的相关性
Correlations between inflammation index,blood lipid index and severity of coronary artery disease in patients with acute coronary syndrome
摘要
Abstract
Objective To investigate the correlations between inflammation index(SII),blood lipid index and the severity of coronary artery disease in patients with acute coronary syndrome(ACS).Methods A total of 100 patients with ACS who were admitted to the First People's Hospital of Lianyungang from March 2021 to March 2024 were selected as the research subjects.There were 58 males and 42 females;aged 38-82(62.50±10.81)years;body mass index 18.20-32.60(25.31±3.52)kg/m2.According to the number of affected blood vessels,the patients were divided into the single-vessel disease group(25 cases)and the multiple-vessel disease group(75 cases).According to the Gensini score,the patients were divided into the mild disease group(32 cases)and the moderate and severe disease group(68 cases).Compare the SII and lipid indicators[total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)]between the single-vessel disease group and the multi-vessel disease group,as well as between the mild disease group and the moderate and severe disease group.The Spearman rank correlation analysis method was used to analyze the correlation between the changes in SII and blood lipid index in ACS patients and the severity of coronary artery lesions.Independent sample t test was used for statistical analysis.Results The levels of TC,TG,LDL-C and SII in the multi-vessel disease group were all higher than those in the single-vessel disease group,while the level of HDL-C was lower than that in the single-vessel disease group(all P＜0.05).The levels of TC,TG,LDL-C and SII in the moderate and severe disease group were all higher than those in the mild disease group,while the level of HDL-C was lower than that in the mild disease group(all P＜0.05).The Spearman rank correlation analysis results showed that the levels of TC,TG,LDL-C and SII were positively correlated with the severity of coronary artery lesions,while the level of HDL-C was negatively correlated with the severity of coronary artery lesions(r=0.272,0.450,0.484,0.374,and-0.479,all P＜0.05).Conclusion The elevated SII level and lipid metabolism disorders in ACS patients are closely related to the severity of coronary artery lesions.The detection of these indicators is helpful for assessing the patient's condition and formulating treatment plans.关键词
急性冠脉综合征/炎症指数/血脂/冠状动脉病变严重程度/相关性Key words
Acute coronary syndrome/Inflammation index/Blood lipid/Severity of coronary artery disease/Correlation引用本文复制引用
许玲,吴红燕,徐瑶,尹德录..急性冠脉综合征患者炎症指数、血脂指标变化与冠状动脉病变严重程度的相关性[J].国际医药卫生导报,2025,31(11):1780-1784,5.基金项目
江苏省卫生健康委员会科研项目(ZDB2020029) Scientific Research Project of Jiangsu Provincial Health Commission(ZDB2020029) （ZDB2020029）
