广州化学2025，Vol.50Issue(3)：41-45,5.DOI:10.16560/j.cnki.gzhx.20250307
碳化钙为乙炔源与腈氧化物合成单取代异恶唑
Synthesis of Monosubstituted Isoxazoles from Nitrile Oxides with Calcium Carbide as Acetylene Source
摘要
Abstract
An efficient and green method has been explored for the synthesis of isoxazoles based on a[3+2]cycloaddition of in situ generated nitrile oxide and calcium carbide.Calcium carbide was used as a safe and easy-to-handle acetylene source for the preparation,without the requirements for specialized high-pressure equipment.The key nitrile oxide intermediates in the synthesis of isoxazoles are formed by treatment of aldoximes with sodium hypochlorite.The method employed aldoximes and calcium carbide as raw materials,trichloromethane as solvent,sodium hypochlorite solution as oxidant at room temperature for 10 hours to synthesize a variety of 3-monosubstituted isoxazole derivatives,with the highest product yield of 86%,has the characteristics of high reaction efficiency and simple conditions.关键词
醛肟/乙炔/碳化钙/环加成反应/异恶唑Key words
aldoxime/acetylene/calcium carbide/cycloaddition reaction/isoxazole分类
化学化工引用本文复制引用
王雪梅,王波,李超,刘楠..碳化钙为乙炔源与腈氧化物合成单取代异恶唑[J].广州化学,2025,50(3):41-45,5.基金项目
山西省基础研究计划资助项目(20210302124637) （20210302124637）
