广州化学2025，Vol.50Issue(3)：71-74,83,5.DOI:10.16560/j.cnki.gzhx.20250316
高水溶性Temoporfin-AlOH-AgNPs-MSA的合成及抗菌性能
Synthesis and Antimicrobial Property of Highly Water-soluble Temoporfin-AlOH-AgNPs-MSA
陈铭睿 1周卓为 2靳焘3
作者信息
- 1. 中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049
- 2. 中科检测技术服务(广州)股份有限公司,广东 广州 510650
- 3. 中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049||中科检测技术服务(广州)股份有限公司,广东 广州 510650||中国科学院新型特种精细化学品工程实验室,广东 广州 510650||国科广化韶关新材料研究院,广东 韶关 512400||国科广化(南雄)新材料研究院有限公司,广东 南雄 512400
- 折叠
摘要
Abstract
A Temoporfin-AlOH-AgNPs-MSA(TMMA)metal-organic material with high water solubility was synthesized by the 1/4 method.And it was determined that the organics were successfully loaded onto the surface of silver nanoparticles by XPS,SEM,TEM,EDS and other material characterization means.And the sterilization efficiency and mechanism of action of the photosensitizer were tested using E.coli as experimental bacteria.The results showed that the E.coli sterilization efficiency increased significantly in the high concentration group and less in the low concentration group with the increase of light exposure time.This reflects the mechanism that the material can generate a large amount of heat to inactivate the bacteria under high concentration conditions,while the low concentration group has only photodynamic effect.The TMMA photosensitizer has a strong antibacterial effect as the inactivation rate of E.coli reached 99.5%at the experimental concentration of 3 mg/mL under the light irradiation for 45 min.关键词
卟啉/银纳米粒子/光敏剂/灭菌/水溶性Key words
Temoporfin/AgNPs/photosensitizer/antimicrobial/water-soluble分类
医药卫生引用本文复制引用
陈铭睿,周卓为,靳焘..高水溶性Temoporfin-AlOH-AgNPs-MSA的合成及抗菌性能[J].广州化学,2025,50(3):71-74,83,5.
