国际医药卫生导报2025，Vol.31Issue(11)：1812-1815,4.DOI:10.3760/cma.j.cn441417-20250106-11010
PI3K/Akt/KDM5A通路在心房颤动中的研究进展
Research progress of P13K/AKT/KDM5A pathway in atrial fibrillation
摘要
Abstract
Cardiac remodeling is the pathological manifestation in the end stages of diseases such as hypertension,myocardial infarction,and heart failure,with myocardial fibrosis being a core component.Numerous studies have confirmed that atrial remodeling is one of the important mechanisms that trigger atrial fibrillation.Among these,the phosphatidylinositol 3-kinase(PI3K)/Serine/Threonine kinase(Akt)signaling pathway regulates the progression of myocardial fibrosis and is closely related to atrial remodeling.However,research on how lysine-specific demethylase 5A(KDM5A)regulates the occurrence of myocardial fibrosis is still in its early stages.Further investigation into the mechanisms of KDM5A in myocardial fibrosis may become one of the effective strategies for treating atrial fibrillation in the future.关键词
心肌纤维化/心房颤动/PI3K/Akt/赖氨酸特异性脱甲基酶5A/综述Key words
Myocardial fibrosis/Atrial fibrillation/PI3K/AKT/KDM5A/Review引用本文复制引用
赵珂,刘振兴,时大宇,徐会圃..PI3K/Akt/KDM5A通路在心房颤动中的研究进展[J].国际医药卫生导报,2025,31(11):1812-1815,4.基金项目
山东省医药卫生科技项目(202303010661) Shandong Province Medical and Health Science and Technology Project(202303010661) （202303010661）
