江西科学2025，Vol.43Issue(3)：481-488,569,9.DOI:10.13990/j.issn1001-3679.2025.03.12
靶向TYK2激酶的小分子抑制剂的设计与开发研究进展
Research Progress on the Design and Development of Small Molecule Inhibitors Targeting TYK2 Kinase
摘要
Abstract
Objective:This study aims to elucidate the design and development process of small molecule inhibitors targeting Tyrosine kinase 2(TYK2)in recent years,as well as to evaluate their potential application value in the treatment of autoimmune diseases.Methods:A comprehensive literature review was conducted to systematically analyze the pharmacological properties,biological activities,and design strategies of TYK2 inhibitors.Results:Compared with non-selective JAK inhibitors,TYK2 inhibitors have demonstrated superior safety and efficacy profiles.Conclusion:The design and development of small molecule TYK2 kinase inhibitors are crucial for creating new,safe,and effective therapeutic agents for autoimmune diseases.The successful approval of Deucravacitinib marks a new era in TYK2-targeted therapy and provides new directions for future drug development.关键词
自身免疫病/酪氨酸激酶2/Janus激酶/小分子抑制剂/药物设计/研究进展Key words
autoimmune diseases/Tyrosine kinase 2/Janus kinases/small molecule inhibitors/drug design/research progress分类
医药卫生引用本文复制引用
杜江南,程建昕..靶向TYK2激酶的小分子抑制剂的设计与开发研究进展[J].江西科学,2025,43(3):481-488,569,9.基金项目
国家自然科学基金项目(22063004). （22063004）
