临床神经病学杂志2025，Vol.38Issue(3)：174-177,4.
替罗非班辅助血管内支架取栓治疗急性基底动脉闭塞脑卒中的临床疗效
Clinical efficacy of tirofiban assisted endovascular stent thrombectomy in the treatment of acute basilar artery occlusion stroke
摘要
Abstract
Objective To analyze the efficacy of tirofiban assisted endovascular stent thrombectomy in the treatment of acute basilar artery occlusion stroke.Methods A total of 100 stroke patients with acute basilar artery occlusion who were treated in the Department of Neurology of Nanyang Central Hospital from May 2020 to May 2023 were selected as the research objects.The patients were divided into a control group and a study group by random number table method,with 50 cases in each group.The control group was treated with endovascular stent thrombectomy,and the study group was treated with tirofiban assisted endovascular stent thrombectomy.The clinical efficacy,surgery related indexes,mRS score,complications,NIHSS score,MMSE score and coagulation function index before and after intervention were compared between the two groups.Results The total effective rate of the study group(56.00％)was significantly higher than that of the control group(36.00％),the number of thrombectomy between the two groups was statistically significant(all P＜0.05).There was no significant difference in the ratio of balloon expansion or stent placement between the two groups.After treatment,the NIHSS cale score of the study group was significantly lower than that of the control group,and the MMSE score was significantly higher than that of the control group(all P＜0.05).After treatment,the levels of serum prothrombin time,fibrinogen and D-dimer in the study group were significantly lower than those in the control group(all P＜0.05).The probability of mRS score ≤2 in the study group(46.00％)was significantly higher than that in the control group(24.00％)(P＜0.05).There was no significant difference in the total incidence of complications between the two groups(10.00％ vs.22.00％).Conclusions Tirofiban assisted endovascular stent thrombectomy can effectively improve the neurological function and mental function of patients with acute basilar artery occlusion stroke,and significantly improve the coagulation function of patients.The prognosis is good and the curative effect is significant,which is worthy of clinical application.关键词
替罗非班/血管内支架取栓/急性基底动脉闭塞脑卒中/神经功能Key words
tirofiban/thrombectomy with intravascular stent/acute basilar artery occlusion stroke/nerve function分类
临床医学引用本文复制引用
裴双,孙军,汪宁,张奇,张在行,李祥欣,周静,温昌明..替罗非班辅助血管内支架取栓治疗急性基底动脉闭塞脑卒中的临床疗效[J].临床神经病学杂志,2025,38(3):174-177,4.基金项目
河南省二○一九年科技发展计划项目(192102310349) （192102310349）
