昆明医科大学学报2025，Vol.46Issue(5)：1-11,11.DOI:10.12259/j.issn.2095-610X.S20250501
脓毒症免疫抑制机制及免疫治疗的研究进展
Research Progress of Immunosuppression Mechanism and Immunotherapy in Sepsis
摘要
Abstract
Sepsis is a syndrome caused by a dysregulated host response to infection that leads to life-threatening organ dysfunction.The immune response in sepsis is usually divided into two stages:hyperimmunity and immunosuppression.Immunosuppression is considered as the main cause of secondary infection and increased mortality in patients.This article reviews the main mechanisms of immunosuppression in sepsis,including dysfunction of immune cells,release of immunosuppressive cytokines,excessive activation of immunomodulatory cells,increased expression of immune checkpoints,and epigenetic dysregulation that have attracted much attention in recent years.At the same time,it also summarizes the existing and some new immunotherapy strategies.It includes immunostimulatory cytokines(such as GM-CSF,IL-7,IL-15),immune checkpoint inhibitors(such as PD-1/PD-L1 antibody,CTLA-4 antibody,TIM-3 antibody)and emerging immunotherapy methods(such as mesenchymal stem cells,calprotectin inhibitors,triggering receptor expressed on myeloid cells 1 inhibitors).This article focuses on epigenetic regulation mechanisms and emerging immunotherapies such as mesenchymal stem cells,aiming to provide theoretical support for individualized precision immunotherapy in patients with sepsis.关键词
脓毒症/免疫抑制/免疫治疗/表观遗传失调Key words
Sepsis/Immunosuppression/Immunotherapy/Epigenetic dysregulation分类
医药卫生引用本文复制引用
黄光仙,王怡洁..脓毒症免疫抑制机制及免疫治疗的研究进展[J].昆明医科大学学报,2025,46(5):1-11,11.基金项目
国家自然科学基金(82460370),云南省急诊创伤性疾病临床医学中心(YWLCYXZX2023300075),云南省老年疾病临床医学研究中心(202102AA310069),云南省创新团队(202305AS350019) （82460370）
