人工晶体学报2025，Vol.54Issue(6)：1005-1012,8.DOI:10.16553/j.cnki.issn1000-985x.2025.0017
甘草酸对一水合草酸钙结晶的抑制作用
Inhibition of the Growth of Calcium Oxalate Monohydrate by Glycyrrhizic Acid
摘要
Abstract
Calcium oxalate monohydrate(COM)is the main component of kidney stones.This study explores the inhibitory effects of glycyrrhizic acid(GlA),a multifunctional natural compound,on the crystallization process of COM and elucidates its mechanism of action.The crystallization kinetics of COM were examined by a calcium ion selective electrode,the impact of GlA on the size and morphology of COM crystals was quantitatively assessed through optical microscopy and scanning electron microscopy.Additionally,molecular simulations were employed to calculate the adsorption energy of GlA molecules on the COM crystal surface.The findings indicate that GlA serves as a highly effective inhibitor of COM crystallization,with the degree of inhibition positively correlating with GlA concentration.This inhibition is attributed to the specific adsorption of GlA on the{021}and{12-1}surfaces of COM,which significantly reduces the crystal aspect ratio.During the COM crystallization process,GlA plays a dual role:it complexes with Ca2+in solution,thereby reducing their effective concentration,and it adsorbs onto the crystal surface via COO-(COM)…Ca2+…-OOC(GlA)interactions,hindering further crystal growth.These findings provide new ideas and potential therapeutic strategies for the prevention and treatment of kidney stones.关键词
一水合草酸钙/甘草酸/结晶动力学/抑制/特异性吸附/络合作用/肾结石Key words
calcium oxalate monohydrate/glycyrrhizic acid/crystallization kinetics/inhibition/specific adsorption/complexation/kidney stone引用本文复制引用
任雅琪,王蕾,李慧敏,曲亚倩,韩培卓,陶绪堂..甘草酸对一水合草酸钙结晶的抑制作用[J].人工晶体学报,2025,54(6):1005-1012,8.基金项目
国家自然科学基金(52472007) （52472007）
山东省自然科学基金(ZR2024ME100) （ZR2024ME100）
山东省泰山学者攀登计划(tapd20221102) （tapd20221102）
111计划2.0(BP2018013) （BP2018013）
