人工晶体学报2025，Vol.54Issue(6)：1013-1020,8.DOI:10.16553/j.cnki.issn1000-985x.2025.0023
基于SBA-15介孔氧化硅递药系统的构建及提高茴拉西坦溶出度的研究
Construction of Drug Delivery System Based on SBA-15 Mesoporous Silica to Improve the Dissolution of Aniracetam
摘要
Abstract
In order to improve the solubility and dissolution of insoluble drug aniracetam(ANI),SBA-15 mesoporous silica carrier was prepared using P123 as template,and the pore-expanded L-SBA-15 carrier with enlarged pore size was obtained using 1,3,5-trimethylbenzene(TMB)as pore-expanding agent.ANI was loaded on two carriers,SBA-15 and L-SBA-15,to construct a drug delivery system based on SBA-15 mesoporous silica.The structure of carrier before and after drug loading was analyzed by SEM,TEM,FTIR,XRD and N2 adsorption-desorption test.It is found that the pore sizes of SBA-15 and L-SBA-15 are 5.04 and 11.92 nm,and the drug loadings are 25.49%and 15.72%,respectively.Compare to the drug dissolution behavior in pH=1.2 and 6.8 dissolution media,it shows that both carriers can significantly improve the dissolution of ANI compared with ANI bulk drug,and the dissolution rate of ANI on L-SBA-15 carrier is slightly faster than that on SBA-15 carrier.This is related to the fact that ANI is highly dispersed in mesoporous materials and is physically adsorbed in mesoporous channels in an amorphous amorphous state,and larger mesopores are more conducive to the diffusion and dissolution of drugs.This study provides some certain experimental basis for improving the dissolution of insoluble drugs in order to increase the bioavailability of such drugs.关键词
介孔氧化硅/SBA-15/茴拉西坦/药物递送系统/溶出度/1,3,5-三甲苯Key words
mesoporous silica/SBA-15/aniracetam/drug delivery system/dissolution/1,3,5-trimethylbenzene引用本文复制引用
牟涵清,吕江维,王鹏光,余科彻,高广宇,张文君..基于SBA-15介孔氧化硅递药系统的构建及提高茴拉西坦溶出度的研究[J].人工晶体学报,2025,54(6):1013-1020,8.基金项目
国家级大学生创新创业训练项目(202410240093) （202410240093）
国家重点研发计划子课题(2022YFD1600502-23) （2022YFD1600502-23）
2023年度新一轮黑龙江省"双一流"学科协同创新成果项目(LJGXCG2023-101) （LJGXCG2023-101）
