日用化学品科学2025，Vol.48Issue(6)：17-23,7.DOI:10.3969/j.issn.1006-7264.2025.06.003
甜菊苷-光甘草定载药液晶霜的在体透皮吸收与皮肤靶向性研究
In Vivo transdermal absorption and skin targeting properties of stevioside Glabridin loaded liquid crystal cream
摘要
Abstract
Using the back skin of mice as the test object,UPLC was used to determine the retention rate of Glabridin in the skin and subcutaneous fat of mice with different dosage forms and different administration times,and to investigate the transdermal absorption effect of liquid crystal cream.The experimental results showed that the 0.5,1,2,4,6 and 8 h skin retention rates of GLA in the liquid crystal cream group were 1.67,0.79,1.73,1.47,1.17 and 1.15 times higher than those of the ordinary cream group under the same dosage of administration,respectively.The 0.5,1,2,4,6 and 8 h fat retention rates of GLA in the normal cream group were 0.86,1.87,1.37,1.20,1.35 and 1.19 times higher than those in the liquid crystal cream group,respectively.Liquid crystal cream can significantly improve the skin retention of GLA,with certain slow and controlled release,and possesses certain skin targeting properties.关键词
液晶霜/光甘草定/甜菊苷/皮肤靶向性Key words
liquid crystal cream/Glabridin/stevioside/skin targeting properties分类
化学工程引用本文复制引用
雷舒帆,宋春敬,王艳,张秀君,王丽峰,文俊雄..甜菊苷-光甘草定载药液晶霜的在体透皮吸收与皮肤靶向性研究[J].日用化学品科学,2025,48(6):17-23,7.基金项目
国家自然科学基金项目(81602773) （81602773）
中国工程院项目(2023-XBZD-11-01) （2023-XBZD-11-01）
