食管疾病2025，Vol.7Issue(2)：94-99,110,7.DOI:10.15926/j.cnki.issn2096-7381.2025.02.003
食管梭形细胞鳞状细胞癌临床病理特征分析
Clinicopathological Features of Esophageal Spindle Cell Squamous Cell Carcinoma
摘要
Abstract
Objective To analyze of the clinicopathological characteristics,morphological features,and prognosis of esophageal spindle cell squamous cell carcinoma(ESCSCC)and improve awareness and diagnostic capabilities for this rare tumor.Methods 80 patients with ESCSCC who underwent radical esophageal resection in Anyang Tumor Hospital from January 2014 to December 2020 were selected.The morphological features related to H&E staining and immunohistochemistry sections were reviewed,and the clinical data and clinicopathological characteristics were analyzed.All patients were followed up to December 2023,and prognosis-related factors were analyzed.Results Among the 80 patients with ESCSCC,the male-to-female ratio was 1.76:1,the median age was 67 years,with the middle oesophageal segment being the most common(58.75％,47/80).In the general morphology,76.25％of the patients had polypoid or exophytic growth.Under the microscope,the morphological characteristics of ESCSCC tumor cells can be divided into two types:squamous and sarcomatoid,with a total of 70 cases,accounting for 87.50％;and all tumors showed a sarcomatoid morphology,with a total of 10 cases,accounting for 12.50％.Prognostic analysis showed that TNM stage(P=0.015)and age of onset of 70 years(P=0.001)were associated with poor prognosis.Conclusion ESCSCC has unique clinical and pathological characteristics,and is more common in elderly males.The lesions are mainly located in the middle of the esophagus,with polyps/umbrella shaped lesions being the most common.The proportion of T1 stage patients is the highest,and prognostic factors incl-ude tumor staging and age.关键词
食管鳞状细胞癌/梭形细胞鳞状细胞癌/病理学形态/临床病理特征Key words
esophageal squamous cell carcinoma/spindle cell squamous cell carcinoma/pathological morphology/clinicopathologic features分类
临床医学引用本文复制引用
徐楠,李军扩,孙媛媛,杨海军..食管梭形细胞鳞状细胞癌临床病理特征分析[J].食管疾病,2025,7(2):94-99,110,7.基金项目
安阳市科技攻关项目(2023C01SF059) （2023C01SF059）
