食管疾病2025，Vol.7Issue(2)：100-105,6.DOI:10.15926/j.cnki.issn2096-7381.2025.02.004
表皮样化生及免疫组化在诊断食管鳞状肿瘤中的应用
Use of Epidermal Metaplasia and Immunohistochemistry in the Diagnosis of Esophageal Squamous Cell Neoplasm
摘要
Abstract
Objective To observe preliminarily the role of esophageal epithelial metaplasia(EEM)and immunohistochemistry in the diagnosis of esophageal squamous cell neoplasm(ESN).Methods 168 esophageal squamous cell neoplasm specimens archived in the pathology database of Anyang Tumor Hospital Pathology Department from March 2023 to February 2024 were selected.The expression of EEM and proteins were observed and analyzed through histological observation and immunohistochemical detection.Results The incidence of EEM in ESN was 17.26％,with blue stained cytoplasmic granules visible on the surface of the esophagus in 82.46％of patients,87.12％of patients who underwent immunohistochemical staining showed P53 protein mutation patterns,and 78.03％of patients showed abnormal Ki-67 expression patterns.Conclusion Joint observation of EEM and immunohistochemical expression can help improve the diagnosis of early ESN with morphological dysplasia.关键词
表皮样化生/免疫组化/食管鳞状肿瘤/前驱病变Key words
epidermal metaplasia/immunohistochemistry/esophageal squamous cell neoplasm/precursor lesions分类
临床医学引用本文复制引用
原玉芬,杨海军,徐楠,孙媛媛,赵帅华,王富强,申敬伟,熊焰,苗兰芳,杜娴娟..表皮样化生及免疫组化在诊断食管鳞状肿瘤中的应用[J].食管疾病,2025,7(2):100-105,6.基金项目
河南省科技攻关项目(232102310222)安阳市科技攻关项目(2023C01SF045) （232102310222）
