汕头大学医学院学报2025，Vol.38Issue(2)：70-74,5.DOI:10.13401/j.cnki.jsumc.2025.02.002
重型创伤性颅脑损伤患者感染特征及肺部感染相关因素分析
Analysis of infection characteristics and pulmonary infection-related factors in patients with severe traumatic brain injury
刘静梅 1张庆英 2杨洪霞 1郑淑端 1谢锦芝 1江卫芝1
作者信息
- 1. 汕头大学医学院第一附属医院重症医学科,广东 汕头 515041
- 2. 汕头大学医学院公共卫生与预防医学教研室,广东 汕头 515041
- 折叠
摘要
Abstract
Objective:To analyze the clinical characteristics and pathogen distribution of infections in patients with severe traumatic brain injury(TBI),and to investigate factors associated with pulmonary infection.Methods:A retrospective cohort study was conducted on 329 severe TBI patients admitted to the intensive care unit of the First Affiliated Hospital of Shantou University Medical College from January 2021 to May 2024.Clinical data were collected to analyze infection types and pathogen profiles.Multivariate logistic regression was used to identify factors associated with pulmonary infection.Results:The overall infection rate was 50.5%(166/329),including 137 cases(41.6%)of single infection,predominantly pulmonary infection(36.8%,121/329),and 29 cases(8.8%)of mixed infection,most commonly pulmonary combined with intracranial infection(3.3%,11/329).A total of 220 pathogenic strains were isolated,with Gram-negative bacteria accounting for 71.8%(158/220),primarily Klebsiella pneumoniae(21.4%)and Pseudomonas aeruginosa(20.9%).Gram-positive bacteria constituted 17.3%(38/220),mainly Staphylococcus aureus(10.9%),while fungi accounted for 10.9%(24/220),predominantly Candida albicans(7.3%).Multivariate logistic regression analysis revealed that tracheotomy(OR=4.129,95%CI:2.255-7.561),feeding intolerance(OR=2.060,95%CI:1.186-3.577),and duration of mechanical ventilation(OR=1.002,95%CI:1.001-1.004)were significantly associated with pulmonary infection in severe TBI patients(all P<0.05).Conclusion:Infections in severe TBI patients are predominantly caused by Gram-negative bacteria,with pulmonary infection being the most common.Tracheotomy,feeding intolerance and prolonged mechanical ventilation may increase the risk of pulmonary infection in severe TBI patients.关键词
颅脑损伤/感染/肺部感染/相关因素Key words
traumatic brain injury/infection/pulmonary infection/related factors分类
医药卫生引用本文复制引用
刘静梅,张庆英,杨洪霞,郑淑端,谢锦芝,江卫芝..重型创伤性颅脑损伤患者感染特征及肺部感染相关因素分析[J].汕头大学医学院学报,2025,38(2):70-74,5.
