世界针灸杂志（英文版）2025，Vol.35Issue(2)：103-108,6.DOI:10.1016/j.wjam.2025.02.002
胶质细胞:在针刺镇痛中的角色
Glial cell:Role of the pain modulation in acupuncture analgesia
摘要
Abstract
The significance of glial cells in the nervous system,particularly in the modulation of pain,has increas-ingly gained prominence,thereby shifting the traditional neurobiological research paradigm that predom-inantly focused on neurons.Acupuncture treatment have been shown to influence the functionality of glial cells,enabling them to serve as modulators that significantly contribute to the inhibition of neuro-genic inflammation,the restoration of synaptic homeostasis,and the enhancement of the pain modulation system.Furthermore,various molecules and their associated signaling pathways facilitate the biological effects of glial cells in the context of acupuncture-induced analgesia.Notably,P2X receptors(P2X3,P2X4,and P2X7),the MAPK pathway(including p38MAPK and ERK),and the JAK/STAT pathway within glial cells are implicated in the modulation of neuroinflammation and pain regulation through acupuncture.These elucidated mechanisms underscore the potential of acupuncture to modulate neuroimmune signal-ing for pain alleviation and suggest the prospect of developing more targeted and effective treatments for chronic pain in the future.关键词
Acupuncture/Analgesia/Nervous system/Glial cells/Signal pathwayKey words
Acupuncture/Analgesia/Nervous system/Glial cells/Signal pathway引用本文复制引用
袁咪,袁澜,陈蔚,宿杨帅,范孟妍,景向红,何伟,王晓宇..胶质细胞:在针刺镇痛中的角色[J].世界针灸杂志（英文版）,2025,35(2):103-108,6.基金项目
This work is funded by Beijing National Science Foundation(No.7222289),the CACMS Innovation Fund(No.CI2021A03404)and the Fundamental Research Funds for the Central Public Welfare Re-search Institutes(No.ZZ2023002). （No.7222289）
