上海针灸杂志2025，Vol.44Issue(6)：674-679,6.DOI:10.13460/j.issn.1005-0957.2025.06.0674
合募配穴电针治疗活动期溃疡性结肠炎的临床研究
Clinical study on electroacupuncture at He-acupoint and Mu-acupoint combinations for active ulcerative colitis
摘要
Abstract
Objective To investigate the clinical effect of electroacupuncture at He-acupoint and Mu-acupoint combinations on clinical symptoms,gut microbiota,serum inflammatory factors,intestinal mucosal barrier function,and quality of life in patients with active ulcerative colitis(UC).Method A prospective randomized controlled trial was conducted on 94 patients with active UC.They were divided into an observation group and a control group,with 47 cases in each group using the random number table method.The control group received conventional Western medication,while the observation group received additional electroacupuncture at He-acupoint and Mu-acupoint combinations based on the control regimen.Changes in Sutherland disease activity index,Mayo endoscopic score,inflammatory bowel disease questionnaire(IBDQ)score,gut microbiota composition,serum markers of intestinal mucosal barrier function(D-lactic acid,diamine oxidase,hypoxia-inducible factor-1α),and inflammatory cytokines(interferon-γ,toll-like receptor 4,monocyte chemoattractant protein-1)were evaluated before and after treatment in both groups.Result After treatment,both groups showed significant reductions in Sutherland index,Mayo endoscopic score,Enterococcus counts,serum markers of mucosal barrier impairment,and inflammatory cytokine levels(P＜0.05),while the counts of Bifidobacterium and Lactobacillus,as well as IBDQ scores,increased significantly(P＜0.05).The observation group showed more significant improvements across all above parameters compared with the control group(P＜0.05).Conclusion Electroacupuncture at He-acupoint and Mu-acupoint combinations,when added to standard Western medication,can effectively alleviate symptoms of active UC,modulate intestinal microbiota,improve serum markers of mucosal barrier and inflammation,and enhance patients'quality of life.关键词
针刺疗法/电针/穴,合(五输)/穴,募/结肠炎,溃疡性/肠道菌群/湿热蕴肠Key words
Acupuncture therapy/Electroacupuncture/Points,He-sea(Five Shu)/Points,Front Mu/Ulcerative colitis/Gut Microbiota/Damp heat in the intestine pattern分类
医药卫生引用本文复制引用
王虎,陈远青,金葵..合募配穴电针治疗活动期溃疡性结肠炎的临床研究[J].上海针灸杂志,2025,44(6):674-679,6.基金项目
浙江省中医药科技计划项目(2023ZL540) （2023ZL540）
