妇儿健康导刊2025，Vol.4Issue(11)：52-56,5.DOI:10.3969/j.issn.2097-115X.2025.11.009
重症呼吸道合胞病毒肺炎患儿临床特征及淋巴细胞亚群分析
Analysis of clinical characteristics and lymphocyte subsets in children with severe respiratory syncytial virus pneumonia
摘要
Abstract
Objective To analyze the clinical characteristics and lymphocyte subsets in children with severe respiratory syncytial virus pneumonia.Methods A total of 61 children with respiratory syncytial virus pneumonia who were hospitalized in Hebei Children's Hospital from November 2016 to July 2023 were selected and divided into the severe group(29 cases)and the non-severe group(32 cases)according to the severity.The clinical data of the children were collected,including general conditions,clinical characteristics,inflammatory indicators and length of hospital stay,etc.The levels of lymphocyte subsets CD3+,CD4+,CD4+/CD8+,CD19+and CD56+were detected by flow cytometry.Results There were no significant differences in gender and disease course before admission between the severe group and non-severe group(P>0.05).The age of onset in the severe group was lower than that in the non-severe group(P<0.05).Both groups had cough,but the incidence of wheezing in the severe group was higher than that in the non-severe group,while the incidence of fever was lower than that in the non-severe group(P<0.05).The length of hospital stay in the severe group was longer than that in the non-severe group(P<0.05).There were no significant differences in white blood cell count,lymphocyte percentage,neutrophil percentage,and C-reactive protein levels between the two groups(P>0.05).The levels of CD3+,CD4+,CD4+/CD8+,CD19+,and CD56+in the severe group were lower than those in the non-severe group(P<0.05),while there was no significant difference in CD8+level between the two groups(P>0.05).Conclusion The main symptom of children with respiratory syncytial virus pneumonia is cough.Clinically,attention should be paid to the levels of CD3+,CD4+,CD4+/CD8+,CD19+,and CD56+in children,with particular focus on the changes in the condition of younger children.关键词
呼吸道合胞病毒/肺炎/临床特征/淋巴细胞亚群Key words
Respiratory syncytial virus/Pneumonia/Clinical characteristic/Lymphocyte subset分类
临床医学引用本文复制引用
褚亚娟,黄坤玲..重症呼吸道合胞病毒肺炎患儿临床特征及淋巴细胞亚群分析[J].妇儿健康导刊,2025,4(11):52-56,5.基金项目
河北省医学科学研究课题计划(20190841). （20190841）
