妇儿健康导刊2025，Vol.4Issue(11)：57-60,4.DOI:10.3969/j.issn.2097-115X.2025.11.010
不同程度生长激素缺乏症患儿生长激素替代治疗效果分析
Analysis of the effect of growth hormone replacement therapy in children with different degrees of growth hormone deficiency
摘要
Abstract
Objective To analyze the effect of recombinant human growth hormone(rhGH)replacement therapy in children with different degrees of growth hormone deficiency(GHD).Methods A total of 51 children with GHD in the 1st Affiliated Hospital of Wenzhou Medical University from February 2018 to February 2022 were selected.According to the peak values of the growth hormone stimulation test,they were divided into the complete growth hormone deficiency group(13 cases)and the partial growth hormone deficiency group(38 cases).Both groups were given rhGH.The levels of serum insulin-like growth factor-1(IGF-1),insulin-like growth factor binding protein-3(IGFBP-3),calcium,phosphorus,vitamins and bone mineral density before and after treatment were compared.The variation range of bone mineral density,height standard deviations(SDs),IGF-1 and IGFBP-3 levels after treatment were compared between the two groups.Results After 6 months of treatment,the levels of serum IGF-1,IGFBP-3 and height SDs of the children increased compared with those before treatment,and the differences were statistically significant(P<0.05).After 6 months of treatment,the bone mineral density of the children increased compared with that before treatment(P<0.05).There were no statistically significant differences in the levels of serum calcium,phosphorus and vitamin D of the children before and after treatment(P>0.05).The variation range of bone mineral density in the complete growth hormone deficiency group was higher than that in the partial growth hormone deficiency group,and the difference was statistically significant(P<0.05).Conclusion rhGH replacement therapy can improve the levels of IGF-1 and IGFBP-3,as well as height and bone mineral density in children with GHD,and has a better effect on improving bone mineral density in children with GHD who are completely deficient in growth hormone.关键词
生长激素缺乏症/重组人生长激素/骨密度/胰岛素样生长因子-1/胰岛素生长因子结合蛋白-3Key words
Growth hormone deficiency/Recombinant human growth hormone/Bone mineral density/Insulin-like growth factor-1/Insulin-like growth factor binding protein-3分类
临床医学引用本文复制引用
金茜茜,黄丽密..不同程度生长激素缺乏症患儿生长激素替代治疗效果分析[J].妇儿健康导刊,2025,4(11):57-60,4.基金项目
温州市基础性医疗卫生科技项目(Y2020077) （Y2020077）
温州市基础性医疗卫生科技项目(Y2020463). （Y2020463）
