中国医疗设备2025，Vol.40Issue(6)：129-133,5.DOI:10.3969/j.issn.1674-1633.20241048
18F-D3FSP PET/CT在阿尔茨海默病临床前期主观认知下降患者中的诊断价值
Diagnostic Value of 18F-D3FSP PET/CT in Patients with Subjective Cognitive Decline in Preclinical Alzheimer's Disease
摘要
Abstract
Objective To investigate the value of 18F-D3FSP positron emission tomography/computed tomography(PET/CT)in diagnosing preclinical subjective cognitive decline(SCD)in Alzheimer's disease.Methods A total of 19 normal control(NC)subjects(NC group)and 42 SCD patients(SCD group)who underwent 18F-D3FSP PET/CT imaging at Hainan Cancer Hospital from January 2021 to December 2022 were enrolled.Clinical characteristics including gender,age and years of education were collected.The standard uptake value ratio(SUVR)of the whole brain was measured.The receiver operating characteristic(ROC)curve was used to analyze the optimal cutoffvalue of whole brain SUVR for diagnosing SCD.The scale scores and SUVR were compared between the NC group and the SCD group,and the ROC curve was applied to evaluate the predictive value of positive indicators for SCD.Results Compared with the NC group,the whole brain SUVR was higher in the SCD group,and the difference was statistically significant(P<0.001).There were no statistically significant differences in years of education,gender,age and scale scores between the two groups(P>0.05).The ROC curve showed that the optimal cutoffvalue of SUVR for diagnosing SCD was 1.122,with an area under the curve of 0.806,a sensitivity of 100.00%,and a specificity of 47.37%.Conclusion 18F-D3FSP PET/CT is a sensitive and reliable detection tool,which can serve as a potential biomarker for the diagnosis of SCD and the assessment of disease progression in future clinical practice.关键词
18F-D3FSP/阿尔茨海默病/主观认知下降/正电子发射计算机断层扫描(PET/CT)/标准摄取值比值/生物标志物Key words
18F-D3FSP/Alzheimer's disease/subjective cognitive decline/positron emission tomography/computed tomography(PET/CT)/standard uptake value ratio/biomarker分类
医药卫生引用本文复制引用
孟凡盛,武冬雪,潘登,熊亮,蒋海壮,于丽娟..18F-D3FSP PET/CT在阿尔茨海默病临床前期主观认知下降患者中的诊断价值[J].中国医疗设备,2025,40(6):129-133,5.基金项目
海南省自然科学基金青年基金(822QN483) （822QN483）
海南省肿瘤医院科研基金(2022QN04). （2022QN04）
