空军军医大学学报2025，Vol.46Issue(6)：721-726,6.DOI:10.13276/j.issn.2097-1656.2025.06.004
基于网络药理学和分子对接探讨沙参麦冬汤防治慢性阻塞性肺病的作用机制
Exploring the mechanism of Decoction of Glehnia and Ophiopogon in preventing and treating chronic obstructive pulmonary disease based on network pharmacology and molecular docking
摘要
Abstract
Objective To explore the active ingredients and pharmacological mechanisms of Decoction of Glehnia and Ophiopogon in the treatment of chronic obstructive pulmonary disease(COPD).Methods The potential active ingredients and targets of Decoction of Glehnia and Ophiopogon were searched through TCMSP and BATMAN-TCM databases.The targets of COPD were obtained through TTD,OMIM,and GeneCards databases.The interaction network of Chinese herbal medicine-component-common target-disease was constructed by Cytoscape 3.8.0 software to obtain the corresponding core components.The protein-protein interaction network of common targets and core targets were obtained through STRING 11.0 database.GO and KEGG pathway enrichment analyses were performed using the DAVID database.AutoDock Vina software was used for molecular docking validation of core components and core targets.Results A total of 224 potential active ingredients were obtained from Decoction of Glehnia and Ophiopogon.COPD was associated with 2 432 targets,and the potential active ingredients had 372 common targets with the disease.The core components included glabridin and medicarpin,while the core targets included STAT3,BCL2,HIF1,etc.KEGG enrichment analysis mainly involved inflammatory response and oxidative stress pathways.The molecular docking results showed that core components had good activity in binding to core targets.Conclusion The main mechanism of Decoction of Glehnia and Ophiopogon in treating COPD may be through the action of core components such as glabridin on targets such as IL6,laying a foundation for further elucidating the pharmacological substance basis and mechanism of action of Decoction of Glehnia and Ophiopogon.关键词
沙参麦冬汤/慢性阻塞性肺病/网络药理学/分子对接/作用机制/炎症反应Key words
Decoction of Glehnia and Ophiopogon/chronic obstructive pulmonary disease/network pharmacology/molecular docking/mechanism of action/inflammatory response分类
中医学引用本文复制引用
钱泓宇,刘时乔,旷湘楠..基于网络药理学和分子对接探讨沙参麦冬汤防治慢性阻塞性肺病的作用机制[J].空军军医大学学报,2025,46(6):721-726,6.基金项目
国家自然科学基金青年科学基金(82405276) （82405276）
河北省中医药管理局科研计划项目(2023116) （2023116）
河北省高等学校科研技术研究项目(BJK2024112) （BJK2024112）
