空军军医大学学报2025，Vol.46Issue(6)：818-822,5.DOI:10.13276/j.issn.2097-1656.2025.06.018
氧化应激在硫芥导致肺损伤中的作用研究进展
Research progress on the role of oxidative stress in lung injury induced by sulfur mustard
摘要
Abstract
Sulfur mustard(SM)is a classic erosive chemical agent with real threat,which can penetrate the human body through multiple ways to cause poisoning.Lung is one of the main target organs of SM poisoning.Lung injury induced by SM includes pulmonary fibrosis,bronchitis,etc.,which is one of the main causes of death caused by SM.So far,the mechanism underlying SM poisoning is unclear,and there are no effective drugs for treatment.Oxidative stress plays a key role in SM-induced lung injury.This paper reviews the recent research progress on oxidative stress in lung injury caused by SM,and mainly introduces the role of oxidative stress in lung injury caused by SM from three aspects:inducing DNA damage,stimulating the synthesis of inflammatory factors and triggering cell apoptosis.The mechanism of SM-induced oxidative stress in lung is also discussed from the perspective of overproduction of reactive oxygen species/reactive nitrogen species and inhibition of antioxidant system leading to the imbalance of redox homeostasis,aiming at providing reference for the research and development of antioxidants.关键词
硫芥/氧化应激/活性氧/肺损伤/抗氧化剂Key words
sulfur mustard/oxidative stress/reactive oxygen species/lung injury/antioxidant分类
医药卫生引用本文复制引用
郭姝君,师敏婕,马耀,赵昱舜,刘思佳,刘江正,孔德钦..氧化应激在硫芥导致肺损伤中的作用研究进展[J].空军军医大学学报,2025,46(6):818-822,5.基金项目
国家自然科学基金(32100996) （32100996）
陕西省自然科学基础研究计划青年项目(2021JQ-343) （2021JQ-343）
