维生素D水平与代谢相关脂肪性肝病患者肝纤维化的相关性OA

Objective To investigate the correlation between different forms of serum vitamin D levels and liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease(MAFLD).Methods Data from the National Health and Nutrition Examination Survey in 2021-2023 were analyzed.Logistic regression models were used to evaluate the relationship between serum total vitamin D,25(OH)D3 levels,and liver fibrosis in the MAFLD patients.Results A total of 2 628 patients were included.There were significant differences between MAFLD patients with liver fibrosis and those without fibrosis in age,smoking history,waist circumference,body mass index,high-density lipoprotein cholesterol,total cholesterol,fasting plasma glucose,hypertension history,vitamin D,and 25(OH)D3 levels(P＜0.05).Logistic regression analysis revealed that compared to the low total serum vitamin D group(11.2-61.8 nmol/L),MAFLD patients with high total vitamin D levels(89.1 nmol/L＜vitamin D≤290 nmol/L)exhibited a 22%reduced risk of liver fibrosis(OR=0.78,95%CI 0.64-0.94,P=0.015).Similarly,compared to the low 25(OH)D3 group(4.1-57.0 nmol/L),those with high 25(OH)D3 level[84.7 nmol/L＜25(OH)D3≤288 nmol/L]showed a 23%lower risk of liver fibrosis(OR=0.77,95%CI 0.62-0.95,P=0.021).After adjusting for covariates,high total vitamin D levels remained significantly associated with reduced liver fibrosis risk(OR=0.63,95%CI 0.42-0.94,P=0.036).Conclusions Elevated serum total vitamin D and 25(OH)D3 levels are protective factors against early liver fibrosis in MAFLD patients.