中国临床医学2025，Vol.32Issue(3)：465-471,7.DOI:10.12025/j.issn.1008-6358.2025.20250295
抑郁症患者睡眠质量在躯体症状与抑郁严重程度间的中介效应
Mediating effect of sleep quality between somatic symptoms and severity of depression in patients with depression
摘要
Abstract
Objective To explore the mediating effect of sleep quality between somatic symptoms and severity of depression in patients with depression.Methods A total of 384 drug-naive patients diagnosed with depression were recruited from the Department of Psychological Medicine of Zhongshan Hospital,Fudan University,during the period from February to August 2024.The severity of depression,somatic symptoms,and sleep quality were assessed using Patient Health Qusetionaire(PHQ)-9,PHQ-15,and Pittsburgh sleep quality index(PSQI),respectively.Based on the PHQ-15 scores,all participants were stratified into two groups:a mild somatic symptoms group(＜10 points,n=136)and a moderate-to-severe somatic symptoms group(≥10 points,n=248).Comparisons of sleep quality between the two groups were conducted,and partial correlation analysis was performed to examine the correlation between sleep quality and somatic symptoms.Additionally,linear regression and mediation analyses were conducted to investigate the mediating effect of sleep quality between somatic symptoms and severity of depression.Results The PSQI scores in moderate-to-severe somatic symptoms group were significantly higher than those in mild somatic symptoms group(P＜0.001).Partial correlation analysis indicated that,after controlling for depression severity,the positive correlation between PSQI and PHQ-15 scores remained significant in both groups(P＜0.01).Regression analysis identified both sleep quality and somatic symptoms as predictors of severity of depression(P＜0.001).Additionally,mediation analysis demonstrated that sleep quality partially mediated the relationship between somatic symptoms and severity of depression,accounting for 26.63%(0.090/0.338)of the total effect.Conclusions In patients with depression,sleep quality is associated with somatic symptoms,and both contribute to an increased risk of the severity of depression.Moreover,sleep quality plays a partial mediating effect between somatic symptoms and severity of depression,highlighting the importance of addressing sleep-related issues in the management of depression.关键词
抑郁症/睡眠质量/躯体症状/中介效应Key words
depression/sleep quality/somatic symptom/mediating effect分类
医药卫生引用本文复制引用
李晓彤,赵泽欣,刘也,李海滨,黄啸..抑郁症患者睡眠质量在躯体症状与抑郁严重程度间的中介效应[J].中国临床医学,2025,32(3):465-471,7.基金项目
国家重点研发计划(2023YFC2506205),上海市卫生健康委员会卫生行业临床研究专项(20214Y0276).Supported by the National Key R&D Program of China(2023YFC2506205)and Special Clinical Research Project of Shanghai Municipal Health Commission(20214Y0276). （2023YFC2506205）
