中国动物检疫2025，Vol.42Issue(6)：55-63,9.DOI:10.3969/j.issn.1005-944X.2025.06.010
宏基因组测序技术在动物源微生物耐药性方面的应用研究进展
Advances in the Application of Metagenomic Sequencing Technology to Animal-derived Microbial Antimicrobial Resistance
方雅红 1孙冰清 1张亦菲 1田恺 1姜芹 1张妤 1蔡煜婷 1商军 1黄士新1
作者信息
- 1. 上海市动物疫病预防控制中心,上海 201103
- 折叠
摘要
Abstract
Antimicrobial resistance(AMR)has been spreading around the world,posing a severe threat to both human and animal health.As animal-derived microorganisms serve as critical reservoirs of antimicrobial resistance genes(ARGs),corresponding monitoring would be of great significance to curb the transmission of AMR from animals to humans or even the environment.With the development of high-throughput sequencing technology,metagenomic sequencing has been widely used in the study of AMR in animal-derived microorganisms.In the paper,the advantages and limitations of metagenomics based on next-and third-generation sequencing in AMR researches were reviewed and analyzed,the direction of AMR researches based on metagenomic sequencing was summarized,the distribution characteristics and transmission mechanisms of ARGs in livestock,aquatic animals and companion animals were integrated,and the challenges and application prospects of the technique were discussed,aiming to theoretically support targeted control of AMR.关键词
宏基因组测序/抗微生物药物耐药性/二代测序/三代测序Key words
metagenomic sequencing/antimicrobial resistance/next-generation sequencing/third-generation sequencing分类
农业科技引用本文复制引用
方雅红,孙冰清,张亦菲,田恺,姜芹,张妤,蔡煜婷,商军,黄士新..宏基因组测序技术在动物源微生物耐药性方面的应用研究进展[J].中国动物检疫,2025,42(6):55-63,9.
