中国动物检疫2025，Vol.42Issue(6)：79-86,98,9.DOI:10.3969/j.issn.1005-944X.2025.06.013
非洲猪瘟病毒干扰先天性免疫的分子机制
Molecular Mechanisms of Interference with Innate Immunity by African Swine Fever Virus
摘要
Abstract
African swine fever virus(ASFV)is a large and complex DNA virus capable of infecting both domestic and wild pigs,posing a significant threat to global pig industry.But there have been no commercial vaccines against the disease except those in Vietnam.ASFV genes and the immunomodulatory capacity of their expression products were strongly correlated with viral virulence and pathogenicity.It has been discovered that the innate immune response produced by infected animals could be suppressed by the virus through a variety of mechanisms.Here,aiming at the complex mechanisms of related proteins of ASFV and host defense,interferon signaling regulation,inflammatory signaling pathway modulation and the effects of apoptosis were systematically summarized,with a view to providing a reference for future development of ASFV vaccines and antiviral drugs.关键词
非洲猪瘟病毒/天然免疫/免疫逃逸/分子机制Key words
ASFV/innate immunity/immune escape/molecular mechanism分类
农业科技引用本文复制引用
于家荣,王筱真,左媛媛,高晟斌,徐蛟,房琳琳,魏荣,包静月,王志亮..非洲猪瘟病毒干扰先天性免疫的分子机制[J].中国动物检疫,2025,42(6):79-86,98,9.基金项目
"十四五"国家重点研发计划项目(2022YFD1800500) （2022YFD1800500）
