中国卒中杂志2025，Vol.20Issue(5)：647-652,6.DOI:10.3969/j.issn.1673-5765.2025.05.012
SPIRIT 2025声明解读:开放科学
Interpretation of the SPIRIT 2025 Statement:Open Science
摘要
Abstract
In April 2025,leading international medical journals such as BMJ,J AMA,and Lancet simultaneously released the updated SPIRIT 2025 statement.This statement is an internationally recognized guidance framework for the development and reporting of clinical trial protocols,aiming to enhance the scientific rigor,transparency,and ethical standards of clinical trial protocols,thereby promoting higher quality and more standardized medical research worldwide.Compared to the SPIRIT 2013,the SPIRIT 2025 statement added two new items,revised five items,deleted three items,and merged two items.Additionally,the overall structure of the checklist was also reorganized,integrating items on trial registration,protocols and statistical analysis plans,data sharing,funding and conflicts of interest,and publication policies into a single open science section.Open science is not merely a technical or policy provision,but a spiritual pursuit embedded in the ethics and values of the scientific community.Achieving open science requires seamless communication at multiple levels,including scientific dissemination,data openness,and method sharing.This article elucidates the definition,historical development,and challenges of open science,enabling readers to deeply understand,support,and participate in open science initiatives in the development of clinical trial protocols.关键词
开放科学/随机试验/临床试验方案/指南Key words
Open science/Randomised trial/Clinical trial protocol/Guideline分类
临床医学引用本文复制引用
李辉,谢雪微..SPIRIT 2025声明解读:开放科学[J].中国卒中杂志,2025,20(5):647-652,6.基金项目
国家自然科学基金面上项目(82471356) （82471356）
