中国动物传染病学报2025，Vol.33Issue(2)：220-226,7.
E3泛素连接酶MARCH1抗病毒感染研究进展
The Host E3 Ligase MARCH1 Antiviral Advances
摘要
Abstract
E3 ubiquitin ligase plays an important role in regulation of intracellular proteins translocation.The host cell MARCH 1 protein is a member of the E3 ubiquitin RING ligase family and executes crucial function in regulating cellular immuno-recognition and immune responses.Recent researches indicate that MARCH 1 molecule also acts actively in cellular immunity against viral infections.At present,there are two typical types of antiviral modes available for MARCH 1.On the one hand,MARCH 1 recognizes the intracellular terminal sequence of viral proteins 1and induces their ubiquitination,thereby targeting them into the intracellular degradation pathways;on the other hand,MARCH 1 retains the viral envelope glycoprotein intracellularly,thereby blocking the viral assembly and the corresponding infection cycles.Here,in this review,we will illustrate the specific antiviral mechanisms of MARCH 1 in the two antiviral modes,which should be beneficial for subsequent antiviral researches.关键词
MARCH1/天然免疫/抗病毒/囊膜糖蛋白/弗林蛋白酶Key words
MARCH1/innate immunity/antiviral/envelope glycoprotein/furin分类
农业科技引用本文复制引用
于长清,彭永刚,张贺,李明翔,徐超,张斌,先元华,汤艳东..E3泛素连接酶MARCH1抗病毒感染研究进展[J].中国动物传染病学报,2025,33(2):220-226,7.基金项目
宜宾职业技术学院自然科学研究重点项目(ZR22ZD-01) （ZR22ZD-01）
