中医药信息2025，Vol.42Issue(6)：41-46,6.DOI:10.19656/j.cnki.1002-2406.20250607
黄连温胆汤加减治疗慢性胃炎伴胆汁反流脾胃湿热证的临床疗效及其对TNF-α、IL-8、PGE2、EGF的影响
Clinical Efficacy of Modified Huanglian Wendan Decoction in Treating Chronic Gastritis with Bile Reflux of Spleen-Stomach Damp-Heat Syndrome and Its Effects on TNF-α,IL-8,PGE2,and EGF
摘要
Abstract
Objective:To observe the clinical efficacy of modified Huanglian Wendan Decoction in treating chronic gastritis with bile reflux of spleen-stomach damp-heat syndrome and its effects on tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),prostaglandin E2(PGE2),and epidermal growth factor(EGF).Methods:A total of 82 patients with chronic gastritis and bile reflux of spleen-stomach damp-heat syndrome who met the inclusion criteria were selected and randomly divided into an observation group and a control group according to a random number table,with 41 cases in each group.During treatment,3 cases dropped out or were excluded in the observation group,and 2 cases dropped out or were excluded in the control group,resulting in 38 cases in the observation group and 39 cases in the control group.The control group was given magnesium aluminum carbonate chewable tablets,while the observation group was given modified Huanglian Wendan Decoction orally.Both groups were treated for 4 weeks.The changes in TCM symptom scores,total syndrome scores,TNF-α,IL-8,PGE2,and EGF levels before and after treatment were compared between the two groups,as well as the clinical efficacy and recurrence rate.Results:The total effective rate in the observation group was 94.74%(36/38),which was higher than that in the control group(82.05%,32/39)(P<0.05).After treatment,the TCM symptom scores and total syndrome scores in both groups were significantly lower than before treatment(P<0.05,P<0.01),and the improvement in the observation group was better than that in the control group(P<0.05,P<0.01).Compared with before treatment,the levels of TNF-α and IL-8 in both groups were significantly decreased after treatment(P<0.01),while the levels of PGE2 and EGF were significantly increased(P<0.01).After treatment,the observation group had lower TNF-α and IL-8 levels than the control group(P<0.01)and higher PGE2 and EGF levels than the control group(P<0.01).At the 6-month follow-up after treatment,the recurrence rate in the observation group was 8.33%(3/36),and that in the control group was 12.5%(4/32).The observation group had a lower recurrence rate,but the difference was not statistically significant.No adverse reactions or toxic side effects occurred in either group during treatment.Conclusion:Modified Huanglian Wendan Decoction shows significant clinical efficacy in treating chronic gastritis with bile reflux of spleen-stomach damp-heat syndrome,and its mechanism may be related to regulating the expression levels of serum TNF-α,IL-8,PGE2,and EGF.关键词
慢性胃炎/胆汁反流/脾胃湿热证/黄连温胆汤/临床研究Key words
Chronic gastritis/Bile reflux/Spleen-stomach damp-heat syndrome/Huanglian Wendan Decoction/Clinical study引用本文复制引用
张瑞,苏坤涵,刘万里..黄连温胆汤加减治疗慢性胃炎伴胆汁反流脾胃湿热证的临床疗效及其对TNF-α、IL-8、PGE2、EGF的影响[J].中医药信息,2025,42(6):41-46,6.基金项目
南京市卫生科技发展项目(YKK21193) （YKK21193）
