中医药信息2025，Vol.42Issue(6)：47-51,56,6.DOI:10.19656/j.cnki.1002-2406.20250608
基于JAK2/STAT3信号通路探讨桂枝芍药知母汤对类风湿关节炎患者Th17/Treg细胞平衡、血清炎症因子的影响
Effects of Guizhi Shaoyao Zhimu Decoction on Th17/Treg Cell Balance and Serum Inflammatory Cytokines in Rheumatoid Arthritis Patients Based on the JAK2/STAT3 Signaling Pathway
摘要
Abstract
Objective:To investigate the effects of Guizhi Shaoyao Zhimu Decoction on th17/treg cell balance and serum inflammatory cytokines in rheumatoid arthritis patients based on the jak2/stat3 signaling pathway.Methods:Seventy-two RA patients who met the inclusion criteria were selected from Luoyang Orthopedic Hospital and randomly divided into a control group and an experimental group,each with 36 patients,according to a random number table.The control group received conventional Western medical treatment,while the experimental group was treated with Guizhi Shaoyao Zhimu Decoction in addition to the conventional treatment for 12 weeks.The Th17/Treg cell balance,JAK2/STAT3 signaling pathway-related proteins,and serum inflammatory cytokine levels were compared between the two groups before and after treatment.Results:Compared with pre-treatment levels,both groups showed a significant decrease in Forkhead Box Protein P3(FOXP3),Interleukin(IL)-17,Transforming Growth Factor-β(TGF-β),IL-2,IL-10,Th17/Treg ratio,JAK2,Phosphorylated JAK2(P-JAK2),STAT3,Phosphorylated STAT3(P-STAT3),Tumor Necrosis Factor-α(TNF-α),C-Reactive Protein(CRP),IL-1,and IL-6(P<0.05).Moreover,the experimental group had lower levels of these indicators than the control group(P<0.05).Conclusion:Guizhi Shaoyao Zhimu Decoction can improve the Th17/Treg imbalance and reduce inflammatory cytokines in RA patients by regulating the JAK2/STAT3 signaling pathway.关键词
桂枝芍药知母汤/类风湿关节炎/辅助性T细胞17/调节性T细胞/蛋白酪氨酸激酶2/信号转导子和转录激活子3/炎症因子Key words
Guizhi Shaoyao Zhimu Decoction/Rheumatoid arthritis/Th17/Treg/JAK2/STAT3/Inflammatory cytokines引用本文复制引用
侯宏理,张雪,靳东亮,于盈盈..基于JAK2/STAT3信号通路探讨桂枝芍药知母汤对类风湿关节炎患者Th17/Treg细胞平衡、血清炎症因子的影响[J].中医药信息,2025,42(6):47-51,56,6.基金项目
河南省中医药科学研究专项课题(2017ZY2117) （2017ZY2117）
