肿瘤防治研究2025，Vol.52Issue(6)：442-447,6.DOI:10.3971/j.issn.1000-8578.2025.24.1332
诱导乳腺癌免疫"冷"转"热"的新策略
Novel Strategies to Transform Breast Cancer From"Cold Tumor"to"Hot Tumor"
摘要
Abstract
Immunotherapy represents the third revolution in the pharmacological treatment of tumors and has demonstrated considerable efficacy in the management of malignant solid tumors,including melanoma and lung cancer.By contrast,breast cancer is frequently categorized as a"cold tumor"because of its limited imm-unogenicity and immunoreactivity,which hinder research progress and clinical outcomes in immunotherapy.Only a small proportion of patients derive benefits from immunotherapeutic interventions,and the development of drug resistance remains a concern.In this regard,novel strategies should be explored for converting immunologically inert"cold tumors"into immunologically active"hot tumors",thereby expanding the population that will benefit from breast cancer immunotherapy.This study reviews new strategies to transform breast cancer from"cold tumor"to"hot tumor".Strategies include enhancing the expression of tumor antigens,promoting immune infiltration,and reversing the immunosuppressive microenvironment.Results also emphasize the importance of comprehensive treatment to enhance systemic immunity.关键词
乳腺癌/免疫治疗/冷肿瘤Key words
Breast cancer/Immunotherapy/Cold tumor分类
临床医学引用本文复制引用
杨凯,储嘉慧,梅杰,殷咏梅..诱导乳腺癌免疫"冷"转"热"的新策略[J].肿瘤防治研究,2025,52(6):442-447,6.基金项目
National Natural Science Foundation of China(No.81972484,82272667) （No.81972484,82272667）
High-level Innovation Team of Nanjing Medical University Program(No.JX102GSP201727) （No.JX102GSP201727）
The Collaborative Innovation Center for Tumor Individualization Program(No.JX21817902/008) （No.JX21817902/008）
Beijing Xisike Clinical Oncology Research Foundation(No.Y-2019AZZD-00680) （No.Y-2019AZZD-00680）
Postgraduate Practice Innovation Program of Jiangsu Province(No.SJCX23_0692) 国家自然科学基金(81972484,82272667) （No.SJCX23_0692）
南京医科大学高水平创新团队项目(JX102GSP201727) （JX102GSP201727）
肿瘤个体化项目协同创新中心(JX21817902/008) （JX21817902/008）
北京市希思科临床肿瘤学研究基金(Y-2019AZZD-00680) （Y-2019AZZD-00680）
江苏省研究生实践创新计划项目(SJCX23_0692) （SJCX23_0692）
