中国当代儿科杂志2025，Vol.27Issue(6)：661-667,7.DOI:10.7499/j.issn.1008-8830.2501047
基于动脉自旋标记技术探讨早产儿脑白质损伤与脑灌注的相关性
Investigating the correlation between white matter injury and cerebral perfusion in preterm infants using arterial spin labeling
孔祥博 1秦璠玥 1段稳丽 1陆林 2郭笑婵 1薛艳然 1洪银钢 1徐发林1
作者信息
- 1. 郑州大学第三附属医院 新生儿科,河南 郑州 450052
- 2. 郑州大学第三附属医院 影像科,河南 郑州 450052
- 折叠
摘要
Abstract
Objective To explore the relationship between white matter injury(WMI)and cerebral perfusion in preterm infants using arterial spin labeling(ASL).Methods A total of 293 preterm infants(gestational age<34 weeks)hospitalized at the Third Affiliated Hospital of Zhengzhou University between June 2022 and June 2024 were included.After achieving clinical stability,the infants underwent brain magnetic resonance imaging(MRI)and ASL.Based on MRI findings,infants were classified into WMI(n=66)and non-WMI(n=227)groups.Cerebral perfusion parameters were compared between groups,and the association between WMI and perfusion alterations was evaluated.Results The WMI group showed a higher incidence of mild intraventricular hemorrhage(IVH)than the non-WMI group(P<0.05).Significantly lower cerebral perfusion was observed in the WMI group across bilateral frontal,temporal,parietal,and occipital lobes,as well as the basal ganglia and thalamus(P<0.05).After adjusting for gestational age,corrected gestational age at ASL scan,and mild IVH,WMI remained significantly associated with reduced regional perfusion(P<0.05).Conclusions WMI in preterm infants correlates with localized cerebral hypoperfusion.ASL-detected perfusion abnormalities may provide novel insights into WMI pathogenesis.关键词
动脉自旋标记/脑白质损伤/脑灌注/感兴趣区/早产儿Key words
Arterial spin labeling/White matter injury/Cerebral perfusion/Region of interest/Preterm infant引用本文复制引用
孔祥博,秦璠玥,段稳丽,陆林,郭笑婵,薛艳然,洪银钢,徐发林..基于动脉自旋标记技术探讨早产儿脑白质损伤与脑灌注的相关性[J].中国当代儿科杂志,2025,27(6):661-667,7.
