中国当代儿科杂志2025，Vol.27Issue(6)：668-674,7.DOI:10.7499/j.issn.1008-8830.2412144
儿童霍奇金淋巴瘤的临床特征及生存分析:一项多中心临床研究
Clinical characteristics and survival analysis of pediatric Hodgkin lymphoma:a multicenter study
摘要
Abstract
Objective To investigate the clinicopathological characteristics and prognostic factors of pediatric Hodgkin lymphoma(HL).Methods A retrospective analysis was conducted on the clinical data of children with newly diagnosed HL from January 2011 to December 2023 at four hospitals:Fujian Medical University Union Hospital,Fujian Medical University Zhangzhou Hospital,First Affiliated Hospital of Xiamen University,and Fujian Children's Hospital.Patients were categorized into low-risk(R1),intermediate-risk(R2),and high-risk(R3)groups based on HL staging and pre-treatment risk factors.The patients received ABVD regimen or Chinese Pediatric HL-2013 regimen chemotherapy.Early treatment response and long-term efficacy were assessed,and prognostic factors were analyzed using the Cox proportional hazards regression model.Results The overall complete response(CR)rates after 2 and 4 cycles of chemotherapy were 42%and 68%,respectively.Compared with the ABVD regimen group,patients treated with the HL-2013 regimen in the R1 group showed significantly higher CR rates after both 2 and 4 cycles(P<0.05).However,no statistically significant differences in CR rates were observed between the two regimens in the R2 and R3 groups(P>0.05).The 5-year event-free survival(EFS)rate,overall survival rate,and freedom from treatment failure rate were 83%±4%,97%±2%,and 88%±4%,respectively.Cox analysis indicated that the presence of a large tumor mass at diagnosis and failure to achieve CR after 4 cycles of chemotherapy were independent risk factors for lower EFS rates(P<0.05).Conclusions Pediatric HL generally has a favorable prognosis.The presence of a large tumor mass at diagnosis and failure to achieve CR after 4 cycles of chemotherapy indicate poor prognosis.关键词
霍奇金淋巴瘤/化疗/预后分析/儿童Key words
Hodgkin lymphoma/Chemotherapy/Prognostic analysis/Child引用本文复制引用
林蓥,郑湧智,潘丽丽,乐少华,李健,郭碧赟,朱玉,翁开枝,罗锦泓,孙高源..儿童霍奇金淋巴瘤的临床特征及生存分析:一项多中心临床研究[J].中国当代儿科杂志,2025,27(6):668-674,7.基金项目
福建省恶性血液病临床医学研究中心(2020Y2006). （2020Y2006）
