肿瘤防治研究2025，Vol.52Issue(6)：461-465,5.DOI:10.3971/j.issn.1000-8578.2025.24.1290
食管癌高发区某自然村16年反流性食管炎样症状观察总结
Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer
摘要
Abstract
Objective To investigate the screening results and factors affecting abnormal detection rates among high-risk groups of esophageal cancer and to explore effective intervention measures.Methods We investigated and collected the information on gender,education level,age,marital status,symptoms of reflux esophagitis(heartburn,acid reflux,belching,hiccup,foreign body sensation in the pharynx,and difficulty swallo-wing),consumption of pickled vegeta-bles,salt use,and esophageal cancer incidence of villagers in a natural village in Wenfeng District,Anyang City,Henan Province.Changes in reflux esophagitis symptoms in the high-incidence area of esophageal cancer before and after 16 years were observed,and the relationship of such changes with esophageal cancer was analyzed.Results In 2008,711 cases were epi-demiologically investigated,including 213 cases with one of the symptoms of reflux esophagitis such as heartburn,acid reflux,belching,hiccups,foreign body sensation in the pharynx,and difficulty swallowing(sorted in accordance with the abovementioned symptoms;if there are multiple symptoms,then the former is taken);55 cases with at least two related symptoms,among which the most symptom was heartburn in 108 cases(15.1%);followed by acid reflux,belching,etc.In 2024,the same group of people was inv-estigated,and eight people were missing because of relocation.A total of 703 people were successfully investigated,of which 189 cases(26.8%)had one of the symptoms of reflux esophagitis,such as heartburn(sorted in accordance with relevant symptoms,if there are multiple symptoms,then the former will be selected);167 cases(23.7%)had at least two related symptoms,among which the most symptom was heartburn in 139 cases(19.7%);followed by acid reflux.Over 16 years,among the 703 people investigated,45 cases had esophageal cancer and they had one or more of the abovementioned symptoms.No significant differences in the reflux esophagitis-like symptoms were found between 2008 and 2024(P=0.26);no significant differences in the compo-sition of reflux esophagitis-like symptoms were found between 2008 and 2024(P=0.299).Conclusion The detection rate of reflux esophagitis-related symptoms in the population in a high-risk area of esophageal cancer has not decreased in the past 16 years,and the high-risk factors still exist.Esophageal cancer is closely related to reflux esophagitis,and clinical practice can provide early diagnosis and treatment for high-risk population.关键词
食管癌/高发区/反流性食管炎/流行病学调查Key words
Esophageal cancer/High-incidence area/Reflux esophagitis/Epidemiological survey分类
临床医学引用本文复制引用
刘军清,韩雪娜,杨卓,钟侃,杨赛,张强,鲍启德,王立东,雷玲玲,付亚如,宋昕,王静静,赵学科,刘敏,范宗民,代方舟..食管癌高发区某自然村16年反流性食管炎样症状观察总结[J].肿瘤防治研究,2025,52(6):461-465,5.基金项目
2025年国家科技重大专项(2024ZD0520900,2024ZD0520906) （2024ZD0520900,2024ZD0520906）
国家自然科学基金面上项目(81872032) （81872032）
河南省濮阳市重大科技专项(210122) 2025 National Science and Technology Major Project(No.2024ZD0520900,2024ZD0520906) （210122）
National Natural Science Foundation of China General Project(No.81872032) （No.81872032）
Major Science and Technology Project of Puyang City,Henan Province(No.210122) （No.210122）
