中国当代儿科杂志2025，Vol.27Issue(6)：702-708,7.DOI:10.7499/j.issn.1008-8830.2410125
儿童克罗恩病不同诱导方案治疗前后营养状况分析
Analysis of nutritional status before and after different induction therapies in children with Crohn's disease
陈蕾蕾 1俞瑜 1罗优优 1陈洁1
作者信息
- 1. 浙江大学医学院附属儿童医院消化科/国家儿童健康与疾病临床医学研究中心,浙江 杭州 310052
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摘要
Abstract
Objective To study the impact of different induction remission therapies on the nutritional status of children with Crohn's disease(CD).Methods A retrospective analysis was conducted on the medical data of 188 children with CD who received induction remission therapy at the Children's Hospital,Zhejiang University School of Medicine from January 2013 to May 2023.The effects of three induction remission therapies—exclusive enteral nutrition(EEN),corticosteroids,and infliximab(IFX)—on height,weight,hemoglobin,and trace elements were compared.Results After induction remission therapy,the weight-for-age Z scores and serum levels of hemoglobin and albumin in all three groups significantly increased(P<0.05),while the height-for-age Z scores showed no change(P>0.05).The levels of folic acid,25-hydroxy vitamin D,serum iron,and total calcium increased,and serum copper levels decreased in the EEN and IFX groups(P<0.05).Vitamin B12 levels improved in the EEN group(P<0.05).Conclusions EEN,corticosteroids,and IFX may effectively improve the weight-for-age Z scores and serum levels of hemoglobin and albumin in children with CD.EEN and IFX seem to be superior to corticosteroid therapy in improving 25-hydroxy vitamin D,folic acid,serum iron,and total calcium levels.关键词
克罗恩病/营养/诱导缓解/儿童Key words
Crohn's disease/Nutrition/Induction remission/Child引用本文复制引用
陈蕾蕾,俞瑜,罗优优,陈洁..儿童克罗恩病不同诱导方案治疗前后营养状况分析[J].中国当代儿科杂志,2025,27(6):702-708,7.
