中国当代儿科杂志2025，Vol.27Issue(6)：746-752,7.DOI:10.7499/j.issn.1008-8830.2501007
基因拷贝数变异在儿童急性B淋巴细胞白血病中的研究进展
Research progress on copy number alterations in pediatric B-cell acute lymphoblastic leukemia
许喜原 1胡群1
作者信息
- 1. 华中科技大学同济医学院附属同济医院儿童血液与肿瘤科,湖北 武汉 430030
- 折叠
摘要
Abstract
Copy number alteration(CNA)is a significant genetic change in pediatric B-cell acute lymphoblastic leukemia(B-ALL),with CDKN2A/B deletions,PAX5 deletions,and IKZF1 deletions being the most common.Recent studies have increasingly highlighted the potential prognostic significance of these gene deletions and multiple co-deletions in pediatric B-ALL.This paper reviews the main detection methods for CNA,as well as the prognostic characteristics and treatment approaches for common CNA in pediatric B-ALL.关键词
急性淋巴细胞白血病/拷贝数异常/预后/治疗/儿童Key words
Acute lymphoblastic leukemia/Copy number alteration/Prognosis/Treatment/Child引用本文复制引用
许喜原,胡群..基因拷贝数变异在儿童急性B淋巴细胞白血病中的研究进展[J].中国当代儿科杂志,2025,27(6):746-752,7.
