安徽医科大学学报2025，Vol.60Issue(6)：1009-1014,6.DOI:10.19405/j.cnki.issn1000-1492.2025.06.005
聚苯乙烯微塑料诱导氧化应激和铁死亡致小鼠心肌损伤作用
Polystyrene microplastics induce oxidative stress and ferroptosis and cause myocardial damage in mice
摘要
Abstract
Objective To investigate the effect of polystyrene microplastics(PS-MPs)on myocardial injury in mice and its molecular mechanism.Methods A total of 60 male C57BL/6 mice were randomly divided into normal sa-line group,0.1,1,10 mg/kg PS-MPs exposed group,and doxorubicin[5 mg/(kg·w)]group treated for 8 weeks.After treatment,we measured blood pressure,cardiac organ coefficient,cardiac histopathological changes,oxidative stress markers reactive oxygen species(ROS),malondialdehyde(MDA),glutathione(GSH),4-hydroxynonenal(4-HNE)and nuclear factor E2-related factor 2(Nrf2),serum centroid injury markers creatine kinase MB(CK-MB)and troponin(cTnT),ferroptosis marker recombinant glutathione peroxidase 4(GPX4),Recombinant solute carrier family 7(SLC7 A11)as well as ferrous ions(Fe2+).Results Compared with the neg-ative control group,vacuolation,inflammatory infiltration and collagen fiber deposition were evident in the hearts of mice after PS exposure.The levels of myocardial injury markers CK-MB and cTnT significantly increased.Cardiac organ coefficient decreased,blood pressure increased,oxidative stress markers and ferroptosis markers increased.Conclusion PS-MPs exposure can induce oxidative stress and activate ferroptosis pathway,resulting in myocardial injury in mice.关键词
聚苯乙烯微塑料/氧化应激/铁死亡/心肌损伤/环境污染物Key words
polystyrene microplastics/oxidative stress/ferroptosis/myocardial damage/environmental contami-nants分类
医药卫生引用本文复制引用
黄琪,朱德育,梁潇,吴金铃,覃文桂,马萍,武阳,鲍翠玉..聚苯乙烯微塑料诱导氧化应激和铁死亡致小鼠心肌损伤作用[J].安徽医科大学学报,2025,60(6):1009-1014,6.基金项目
国家自然科学基金(编号:42177416) （编号:42177416）
湖北科技学院医学科研专项重点项目(编号:2022YKY01) （编号:2022YKY01）
咸宁市科技计划项目(编号:2023SFYF095) （编号:2023SFYF095）
湖北科技学院科研创新团队项目(编号:2023T08) National Natural Science Foundation of China(No.42177416) （编号:2023T08）
Medical Research Key Project of Hubei University of Science and Technology(No.2022YKY01) （No.2022YKY01）
Project in Science and Technology Planning of Xianning City(No.2023SFYF095) （No.2023SFYF095）
Scientific Research Innovation Team Project of Hubei University of Science and Technology(No.2023T08) （No.2023T08）
