多囊卵巢综合征中线粒体自噬与铁死亡之间串联关系
The interconnected relationship between mitochondrial autophagy and ferroptosis in polycystic ovary syndrome
摘要
Abstract
Polycystic ovarian syndrome(PCOS)is a very common endocrine and reproductive disease.Its etiology and pathogenesis are complex and not yet fully clear.At present,the clinical treatment is mainly symptomatic.Studies have revealed that ferroptosis,as a new form of cell death,may play a key regulatory role in the occurrence and development of PCOS.In addition,there is an increase in autophagy/mitochondrial autophagy in PCOS pa-tients,which may be closely related to the occurrence of ferroptosis.This review summarizes the pathogenesis of mitochondrial autophagy and ferroptosis in PCOS,and analyzes the interrelationship between mitochondrial autoph-agy and ferroptosis in granulosa cells,in order to provide new insights and potential therapeutic targets for the clini-cal treatment of PCOS.关键词
多囊卵巢综合征/线粒体自噬/铁死亡/串联机制/颗粒细胞Key words
polycystic ovary syndrome/mitochondrial autophagy/ferroptosis/tandem mechanism/granulosa cells分类
医药卫生引用本文复制引用
赵琦,陈萍,杨丽萍,孙建华..多囊卵巢综合征中线粒体自噬与铁死亡之间串联关系[J].安徽医科大学学报,2025,60(6):1149-1154,6.基金项目
国家自然科学基金(编号:81973596、82004412) （编号:81973596、82004412）
河南中医药大学博士科研启动基金(编号:RSBSJJ2019-29) （编号:RSBSJJ2019-29）
河南省中医药传承与创新人才工程(仲景工程)中医药青苗人才培养项目(编号:豫卫中医函[2021]16号) （仲景工程）
河南省中医药科学研究专项课题(编号:2024ZY3006) （编号:2024ZY3006）
河南省重点研发专项(编号:241111310900) National Natural Science Foundation of China(Nos.81973596,82004412) （编号:241111310900）
Doctoral Start-up Foundation of Henan University of Chinese Medicine(No.RSBSJJ2019-29) （No.RSBSJJ2019-29）
Traditional Chinese Medicine Inherit-ance and Innovation Talent Project(Zhongjing Project)Traditional Chinese Medicine Youth Talent Training Pro-gram of Henan Province(YuWei Chinese Medicine[2021],No.16) （Zhongjing Project）
Special Project of Traditional Chinese Med-icine Scientific Research of Henan Province(No.2024ZY3006) （No.2024ZY3006）
Key Research and Development Program of Henan Province(No.241111310900). （No.241111310900）
