巴楚医学2025，Vol.8Issue(2)：1-8,8.DOI:10.3969/j.issn.2096-6113.2025.02.001
肺血管内皮屏障功能障碍与脓毒症急性肺损伤最新研究进展
The Latest Research Progress on Dysfunction of Pulmonary Vascular Endothelial Barrier and Sepsis-Induced Acute Lung Injury
摘要
Abstract
The lung,with the most abundant capillaries and the largest area of endothelium in the body,is one of the most vulnerable target organs for sepsis,and acute lung injury(ALI)can occur in the early stages of sepsis.As an important oxygen transport organ,the lung has extensive interactions with other organs.Lung injury due to sepsis can aggravate dysfunction of other organs,ultimately increasing patient mortality.The activation and/or dysfunction of diffuse pulmonary vascular endothelial cells(VEC)not only causes sepsis-induced ALI,but also leads to damage to extrapulmonary organs such as the brain,kidneys,and heart due to organ interactions,further aggravating sepsis-induced multiple organ dysfunction.This article reviews the pathophysiological mechanisms of lung VEC dysfunction and sepsis-induced ALI.关键词
脓毒症/血管内皮细胞功能障碍/急性肺损伤/急性呼吸窘迫综合征Key words
sepsis/vascular endothelial cell dysfunction/acute lung injury(ALI)/acute respiratory distress syndrome分类
临床医学引用本文复制引用
周高生,王小亭,刘大为..肺血管内皮屏障功能障碍与脓毒症急性肺损伤最新研究进展[J].巴楚医学,2025,8(2):1-8,8.基金项目
国家自然科学基金项目(81671878) （81671878）
首都临床诊疗技术研究及转化应用项目(Z201100005520038) （Z201100005520038）
北京市自然科学基金面上项目(7232126) （7232126）
宜昌市医疗卫生科研项目(A24-2-011) （A24-2-011）
北京重症超声研究会专题科研项目(2023-CCUSG-A-03) （2023-CCUSG-A-03）
