巴楚医学2025，Vol.8Issue(2)：51-56,6.DOI:10.3969/j.issn.2096-6113.2025.02.008
极低出生体重早产儿支气管肺发育不良的影响因素分析
Analysis of Influencing Factors of Bronchopulmonary Dysplasia in Very Low Birth Weight Preterm Infants
摘要
Abstract
Objective:To explore the independent influencing factors of bronchopulmonary dysplasia(BPD)in very low birth weight(VLBW)preterm infants.Methods:A retrospective analysis was conducted on 144 VLBW preterm infants(birth weight＜1 500 g,gestational age＜37 weeks)born at Yichang Central People's Hospital from January 2020 to December 2023.They were divided into BPD group(u=56)and non-BPD group(n=88)based on whether they had BPD.Multivariate Logistic regression analyses were performed to identify the independent influencing factors for BPD in VLBW preterm infants.Receiver operating characteristic curves were plotted,and the area under the curve(AUC)was calculated.Results:Significant differences were observed between the two groups in birth weight,gestational age,breastfeeding,reticulocyte count,thyroid-stimulating hormone,time off oxygen,and time to first feeding(all P＜0.05).Multivariate Logistic regression analysis revealed that invasive ventilatory support(OR=5.809,95％CI:1.079,31.292)and prolonged parenteral nutrition(OR=1.836,95％CI:1.399,2.408)were independent risk factors for BPD in VLBW preterm infants,while increased gestational age(OR=0.277,95％CI:0.139,0.549)was an independent protective factor(all P＜0.05).The AUC values for parenteral nutrition,gestational age,and invasive ventilatory support were 0.932,0.876,and 0.750,respectively.The diagnostic cut-off for gestational age and duration of parenteral nutrition were determined by Youden's index to be 30.8 weeks and 20.5 days,respectively.Conclusion:Invasive ventilatory support and prolonged parenteral nutrition are independent risk factors for BPD in preterm infants.Efforts should be made during the perinatal period to prolong the gestational age of preterm infants to reduce complications.关键词
极低出生体重/早产儿/支气管肺发育不良/影响因素Key words
very low birth weight(VLBW)/preterm infants/bronchopulmonary dysplasia(BPD)/influencing factors分类
医药卫生引用本文复制引用
黄志伟,芦伟,周慧..极低出生体重早产儿支气管肺发育不良的影响因素分析[J].巴楚医学,2025,8(2):51-56,6.基金项目
湖北陈孝平科技发展基金项目(CXPJJH121002-202113) （CXPJJH121002-202113）
湖北省儿科联盟医学科研项目(HBPAMR-2021-16) （HBPAMR-2021-16）
