巴楚医学2025，Vol.8Issue(2)：57-62,6.DOI:10.3969/j.issn.2096-6113.2025.02.009
丙泊酚联合阿芬太尼在小儿支气管肺泡灌洗术中的疗效分析
Efficacy Analysis of Propofol Combined with Alfentanil in Pediatric Bronchoalveolar Lavage
摘要
Abstract
Objective:To explore the application effect of propofol combined with alfentanil in pediatric bronchoalveolar lavage(BAL).Methods:A total of 100 children who underwent BAL treatment at Yichang Central People's Hospital from March 2021 to December 2023 were selected and randomly divided into observation group(n=50)and control group(n=50).The observation group was treated with propofol combined with alfentanil,while the control group was treated with propofol combined with sufentanil.Surgical-related indicators,oxidative stress indicators,respiratory mechanics indicators,and adverse reactions were recorded for both groups.Results:Compared with the control group,the observation group had a significantly higher success rate of first-time laryngeal mask airway(LMA)insertion(98.00％vs 86.00％),better LMA insertion conditions(98.00％vs 84.00％),and shorter withdrawal time of LMA[(3.72±1.07)min vs(6.01±0.86)min]and awakening time after discontinuation of medication[(6.22±1.54)min vs(8.77±1.05)min],and postanesthesia care unit stay time[(13.05±4.23)min vs(16.04±4.01)min](all P＜0.05).At the time of fiberoptic bronchoscopy passing through the glottis(T2)and at the end of the procedure(T3),the malondialdehyde(MDA)in the observation group was significantly lower,while the superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were significantly higher than those in the control group(all P＜0.05).At T2 and T3,the peak airway pressure(Ppeak)and mean airway pressure(Pmean)in the observation group were significantly less than those in the control group(all P＜0.05).There was no significant difference in adverse reactions between the two groups of children.Conclusion:The application of propofol combined with alfentanil in pediatric BAL can improve the anesthetic effect,shorten the recovery time,reduce oxidative stress,and lower airway pressure,making it worthy of clinical promotion in anesthesia.关键词
阿芬太尼/丙泊酚/支气管肺泡灌洗术/氧化应激/苏醒时间Key words
alfentanil/propofol/bronchoalveolar lavage(BAL)/oxidative stress/recovery time分类
临床医学引用本文复制引用
陶虓嫣,刘怡菲,许晴雯,舒爱华..丙泊酚联合阿芬太尼在小儿支气管肺泡灌洗术中的疗效分析[J].巴楚医学,2025,8(2):57-62,6.基金项目
湖北省教育厅科学技术研究项目(B2021029) （B2021029）
