巴楚医学2025，Vol.8Issue(2)：74-78,5.DOI:10.3969/j.issn.2096-6113.2025.02.012
不同剂量氨甲环酸在股骨转子间骨折患者中的临床疗效分析
Analysis of the Clinical Efficacy of Different Doses of Tranexamic Acid in Patients with Intertrochanteric Femoral Fractures
摘要
Abstract
Objective:To explore the clinical efficacy of different doses of intravenous tranexamic acid(TXA)administered preoperatively in patients with intertrochanteric femoral fractures.Methods:A retrospective analysis was conducted on the clinical data of 98 patients who underwent surgical treatment for intertrochanteric femoral fractures at Yichang Central People's Hospital between January 2023 and July 2024.Based on the preoperative use of TXA,the patients were divided into a conventional group without TXA administration(n=27),the low-dose group with intravenous injection of 0.5 g TXA(n=40),and the high-dose group with intravenous injection of 2 g TXA(n=31).The intraoperative visible blood loss,invisible blood loss,total blood loss,postoperative changes in hemoglobin levels,and complications were compared among these three groups.Results:The high-dose group had significantly lower intraoperative visible blood loss,invisible blood loss,and total blood loss than the conventional and low-dose groups.The hemoglobin levels on postoperative days 1,3,and 5 were significantly higher in the high-dose group than in the conventional and low-dose groups(all P＜0.05).There was no significant difference in the incidence of complications among these three groups of patients.Conclusion:Preoperative intravenous administration of TXA can reduce perioperative blood loss and complications in patients with intertrochanteric femoral fractures,with the high-dose TXA demonstrating superior efficacy.关键词
氨甲环酸/股骨转子间骨折/出血量Key words
tranexamic acid(TXA)/intertrochanteric femoral fracture/blood loss volume分类
医药卫生引用本文复制引用
郭辉福,吴飞,寿康全,张恒,杨华瑞,刘健..不同剂量氨甲环酸在股骨转子间骨折患者中的临床疗效分析[J].巴楚医学,2025,8(2):74-78,5.基金项目
湖北省自然科学基金项目(2021CFB488) （2021CFB488）
湖北省卫健委西医类重点项目(WJ2015MA025) （WJ2015MA025）
