巴楚医学2025，Vol.8Issue(2)：79-84,6.DOI:10.3969/j.issn.2096-6113.2025.02.013
血清IL-17和MMP-13对膝关节骨性关节炎患者行膝关节外侧支持带松解术预后不良的预测价值
Predictive Value of Serum IL-17 and MMP-13 for Poor Prognosis after Lateral Retinacular Release in Patients with Knee Osteoarthritis
摘要
Abstract
Objective:To explore the predictive value of serum interleukin-17(IL-17)and matrix metalloproteinase-13(MMP-13)for poor prognosis in patients with knee osteoarthritis(KOA)undergoing arthroscopic lateral retinacular release.Methods:A total of 86 patients with KOA treated at Yichang Central People's Hospital from January 2023 to June 2024 were retrospectively analyzed.All patients underwent arthroscopic lateral retinacular release.Patients with a Lysholm score＜85 at 3 months postoperatively were assigned to the poor prognosis group(n=25),while those with a score ≥85 were assigned to the good prognosis group(n=61).Serum levels of IL-17 and MMP-13 were measured preoperatively and at 3 months postoperatively.The correlation between serum markers and postoperative prognosis was analyzed using point-biserial correlation coefficient.The predictive value of serum markers for poor postoperative prognosis was evaluated using receiver operating characteristic(ROC)curves.Results:Preoperative serum IL-17 and MMP-13 levels were significantly higher in the poor prognosis group compared to the good prognosis group,and both markers were significantly reduced postoperatively in both groups(all P＜0.05).Preoperative serum IL-17 and MMP-13 levels were positively correlated with poor prognosis.The areas under the ROC curve(AUC)for IL-17,MMP-13,and their combination in predicting poor prognosis were 0.917,0.894,and 0.982,respectively.Conclusion:Elevated serum IL-17 and MMP-13 levels are associated with poor prognosis after arthroscopic lateral retinacular release in KOA patients.The combination of IL-17 and MMP-13 has high predictive value for poor postoperative outcomes.关键词
膝关节骨性关节炎/外侧支持带松解术/白细胞介素-17/基质金属蛋白酶-13/预后不良Key words
knee osteoarthritis(KOA)/lateral retinacular release/interleukin-17(IL-17)/matrix metalloproteinase-13(MMP-13)/poor prognosis分类
医药卫生引用本文复制引用
邹亮,寿康全..血清IL-17和MMP-13对膝关节骨性关节炎患者行膝关节外侧支持带松解术预后不良的预测价值[J].巴楚医学,2025,8(2):79-84,6.基金项目
湖北省自然科学基金项目(2021CFB488) （2021CFB488）
