摘要
Abstract
Diabetic foot ulcer,as one of the most severe chronic complications of diabetes,has a complex pathogenesis involving the interplay of multiple factors such as chronic inflammation,immune microenvironment imbalance,and angiogenesis disorder.Although modern medicine has made progress in debridement and anti-infection treatments,the high recurrence and disability rates remain clinical challenges.Traditional Chinese medicine(TCM),based on the theories of"digital gangrene"and"sinew abscess",proposes the core pathogenesis as"deficiency,stasis,and toxicity".Through therapeutic methods such as invigorating qi to resolve stasis and supporting the healthy qi to expel toxins,TCM significantly improves local microcirculation,regulates macrophage polarization,inhibits activation of the NLRP3 inflammasome,and clears biofilms via multi-target mechanisms,thereby promoting angiogenesis and tissue repair.This article systematically reviews the classical TCM theories and recent research advances,revealing the TCM pathogenesis of diabetic foot ulcer and its synergistic effects in regulating chronic inflammation,correcting immune imbalance,and improving angiogenesis disorder,providing a theoretical basis for integrated TCM and Western medicine diagnosis and treatment.However,current research still faces issues including the lack of a unified TCM pathogenesis theory,insufficient depth in compound mechanism studies,and absence of standardized clinical efficacy evaluation.Future research should integrate systems biology and artificial intelligence technologies to construct a dynamic"syndrome-pathology-molecular network"model,promoting precision and internationalization of TCM development and achieving a complete chain from basic research to clinical translation.关键词
糖尿病足溃疡/发病机制/慢性炎症/中医药研究现状Key words
diabetic foot ulcer/pathogenesis/chronic inflammation/current research status of traditional Chinese medicine
