北京中医药2025，Vol.44Issue(5)：566-570,5.DOI:10.16025/j.1674-1307.2025.05.006
益胃解毒方联合复胃散胶囊治疗脾胃虚弱型幽门螺杆菌阳性胃癌前病变临床观察
Clinical observation of Yiwei Jiedu Formula combined with Fuweisan Capsules in the treatment of Helicobacter pylori-positive gastric precancerous lesions with spleen and stomach deficiency syndrome
摘要
Abstract
Objective To observe the clinical efficacy of Yiwei Jiedu Formula combined with Fuweisan Capsules in treating Helicobacter pylori(Hp)-positive gastric precancerous lesions with spleen and stomach deficiency syndrome.Methods A total of 150 patients with Hp-positive gastric precancerous lesions admitted to Shijiazhuang Hospital of Traditional Chinese Medicine from June 2019 to June 2022 were enrolled and randomly divided into three groups using a random number table method,with 50 cases in each group.Control group A was treated with Yiwei Jiedu Formula,control group B was treated with Fuweisan Capsules,and the observation group received Yiwei Jiedu Formula combined with Fuweisan Capsules.Each group was treated continuously for three courses,with each course lasting four weeks.Gastroscopic pathological scores(including gastric mucosal atrophy,intestinal metaplasia,dysplasia,and inflammatory activity),gastric function indicators[pepsinogen I(PG I),pepsinogen II(PG II),gastrin-17(G-17)],expression levels of translocation gene C(C-myc),proto-oncogene(c-erbB-2),and inflammatory factors[heat shock protein 70(HSP70),interleukin-10(IL-10),serum amyloid A(SAA)]were observed before and after treatment,along with clinical efficacy comparison.Results The total effective rate in the observation group was higher than that in control group A and control group B(P<0.05).After treatment,gastroscopic pathological scores in the observation group were lower than those in the two control groups(P<0.05).Gastric function indicators(PG I,PG II,G-17),C-myc,c-erbB-2,and inflammatory factors(HSP70,IL-10,SAA)were also significantly lower in the observation group compared with the control groups(P<0.05).There was no significant difference in the incidence of adverse reactions among the observation group,control group A,and control group B during treatment(P>0.05).Conclusion Yiwei Jiedu Formula combined with Fuweisan Capsules effectively improves gastric mucosal pathological changes and gastric function,inhibits the expression of C-myc,c-erbB-2,and inflammatory factors,and is clinically effective with good safety in the treatment of Hp-positive gastric precancerous lesions.关键词
胃癌前病变/幽门螺杆菌/益胃解毒方/复胃散胶囊Key words
gastric precancerous lesions/Helicobacter pylori/Yiwei Jiedu Formula/Fuweisan Capsules引用本文复制引用
王立业,张艳彬,朱亚楠,王冲,李晶,柳康康,徐晓炜,朱玉光..益胃解毒方联合复胃散胶囊治疗脾胃虚弱型幽门螺杆菌阳性胃癌前病变临床观察[J].北京中医药,2025,44(5):566-570,5.基金项目
河北省中医药管理局科研计划项目(20203602102) （20203602102）
