川北医学院学报2025，Vol.40Issue(6)：759-763,5.DOI:10.3969/j.issn.1005-3697.2025.06.017
哌拉西林钠他唑巴坦钠联合盐酸氨溴索对重症肺炎患者痰液性状、肺部炎症及呼吸力学的影响
Effect of piperacillin sodium and tazobactam sodium for injection combined with ambroxol hydrochloride on sputum characteristics,pulmonary inflam-mation,and respiratory mechanics in patients with severe pneumonia
摘要
Abstract
Objective:To explore the effect of piperacillin sodium and tazobactam sodium for injection combined with ambroxol hydrochloride on sputum characteristics,pulmonary inflammation,and respiratory mechanics in patients with severe pneumonia(SP).Methods:A total of 106 patients with SP were divided into the control group and the observation group according to different treatment methods,with 53 cases in each group.On the conventional treatment basis,the control group was treated with piperacillin sodium and tazobactam sodium for injection,and the observation group was treated with ambroxol hydrochloride on the basis of the treatment of con-trol group.After 14 d of treatment,the two groups were compared on clinical efficacy,clinical indicators,sputum characteristic scores,inflammatory indicators,and respiratory mechanics indicators.The occurrence of adverse reactions was recorded.Results:After 14 d of treatment,the total effective rate,bacterial clearance rate,sputum volume score,and dynamic lung compliance of the observation group were higher compared with the control group(P＜0.05).The duration of fever,duration of mechanical ventilation,sputum change time,cough and sputum characteristic scores,C-reactive protein,tumor necrosis factor,procalcitonin,work of breathing and peak airway pres-sure were lower than those of the control group(P＜0.05).The incidence rates of adverse reactions in the two groups during treatment were 7.55%and 11.32%,with no significant difference(P>0.05).Conclusion:Piperacillin sodium and tazobactam sodium for in-jection combined with ambroxol hydrochloride is effective in the treatment of SP,which can effectively improve sputum characteristics and respiratory mechanics,and alleviate pulmonary inflammation,with good safety.关键词
注射用哌拉西林钠他唑巴坦钠/氨溴索/重症肺炎/炎症反应/呼吸力学Key words
Piperacillin sodium and tazobactam sodium for injection/Ambroxol/Severe pneumonia/Inflammatory response/Re-spiratory mechanics分类
医药卫生引用本文复制引用
郭晓霞,刘美兰,邢星,郑义,刘建康..哌拉西林钠他唑巴坦钠联合盐酸氨溴索对重症肺炎患者痰液性状、肺部炎症及呼吸力学的影响[J].川北医学院学报,2025,40(6):759-763,5.基金项目
河北省卫生健康委医学科学研究课题(20220309) （20220309）
