川北医学院学报2025，Vol.40Issue(6)：782-786,5.DOI:10.3969/j.issn.1005-3697.2025.06.022
巴曲酶联合阿司匹林对下肢骨折伴深静脉血栓患者急性期凝血功能、炎症反应及症状的影响
Effect of baclofen combined with aspirin on coagulation function,inflam-matory response,and symptoms in patients with lower limb fractures ac-companied by deep vein thrombosis during the acute phase
摘要
Abstract
Objective:To explore the effects of batroxobin injection combined with enteric-coated aspirin on coagulation func-tion,inflammatory response,and symptoms in patients with deep vein thrombosis following lower limb fractures during the acute phase.Methods:A total of 108 patients with lower limb fractures complicated by deep vein thrombosis were divided into a control group and an observation group according to different treatment methods,with 54 cases in each group.The control group received treatment with enter-ic-coated aspirin,while the observation group received batroxobin injection in addition to aspirin treatment,lasting for 7 days.Both groups continued treatment with enteric-coated aspirin for 7 months to consolidate the therapeutic effect.After 7 days of treatment,the efficacy,coagulation function,blood rheology,inflammation,venous blood flow velocity,lower limb circumference,pain[Visual Analog Scale(VAS)],lower limb symptoms,and incidence of adverse reactions were recorded and compared between the two groups.Results:The effective rate of treatment in the observation group was higher than that in the control group(92.59%vs.77.78%,P＜0.05).Af-ter treatment,the activated partial thromboplastin time(APTT)in the observation group was higher than that in the control group(P＜0.05),while fibrinogen(FIB),prothrombin time(PT),whole blood high shear viscosity,and whole blood low shear viscosity levels were all lower than those in the control group(P＜0.05).Additionally,levels of hypersensitive C-reactive protein(hs-CRP),procalci-tonin(PCT),and interleukin-6(IL-6)in the observation group were lower than those in the control group(P＜0.05).The venous blood flow velocity in the observation group was higher than that in the control group(P＜0.05),and the lower limb circumference,VAS score,lower limb swelling,skin color,and cord-like or nodular scoring were all lower than those in the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For pa-tients with deep vein thrombosis following lower limb fractures,the short-term efficacy of batroxobin injection combined with enteric-coated aspirin is significant,beneficial for improving coagulation function and blood rheology indicators during the acute phase,and helps reduce inflammation and pain levels,effectively improving lower limb symptoms.It is worthy of clinical promotion and application.关键词
巴曲酶注射液/阿司匹林肠溶片/下肢深静脉血栓/凝血功能/炎症/短期疗效Key words
Batroxobin injection/Aspirin enteric-coated tablets/Lower extremity deep vein thrombosis/Coagulation/Inflamma-tion/Short-term efficacy分类
医药卫生引用本文复制引用
韩新峰,霍景山,杨志林..巴曲酶联合阿司匹林对下肢骨折伴深静脉血栓患者急性期凝血功能、炎症反应及症状的影响[J].川北医学院学报,2025,40(6):782-786,5.基金项目
广东省佛山市卫生健康局医学科研项目(20220463) （20220463）
